Incidence increasing along with number of patients who are overweight or obese.
Associated with increased cardiovascular risk.
May cause acute pancreatitis when fasting levels >500 mg/dL.
Treatment includes lifestyle modification for all patients.
Statins are generally first-line pharmacotherapy in patients with triglycerides <500 mg/dL in the presence of ≥2 cardiac risk factors.
Fibric acid derivatives, fish oils, and/or niacin may be added to statins, to achieve targets, in patients with triglycerides <500 mg/dL, or as first-line therapy in those with triglycerides ≥500 mg/dL.
Hypertriglyceridemia is defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) as fasting plasma triglyceride level ≥200 mg/dL. Borderline high is defined as 150 to 199 mg/dL, high as 200 to 499 mg/dL, and very high as ≥500 mg/dL.   Chylomicronemia is present when a triglyceride level is ≥1000 mg/dL.
Professor of Medicine
Playa Vista Medical Center
DAL is an author of several references cited in this monograph.
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