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Autoimmune hepatitis

Last reviewed: 19 Aug 2025
Last updated: 22 Mar 2024

Summary

Definition

Anamnesis y examen

Principales factores de diagnóstico

  • fatigue/malaise
  • anorexia
  • abdominal discomfort
  • hepatomegaly
  • jaundice
  • encephalopathy
Todos los datos

Otros factores de diagnóstico

  • pruritus
  • arthralgia
  • nausea
  • amenorrhea
  • spider angiomata
  • fever
  • maculopapular skin rash
  • gastrointestinal bleeding
  • splenomegaly
  • ascites
Todos los datos

Factores de riesgo

  • female sex
  • genetic predisposition
  • immune dysregulation
  • measles virus
  • cytomegalovirus
  • Epstein-Barr virus
  • hepatitis viruses A, C, and D
  • certain drugs
Todos los datos

Pruebas diagnósticas

Primeras pruebas diagnósticas para solicitar

  • aspartate transaminase
  • alanine transaminase
  • bilirubin
  • gamma glutamyl transferase (gamma-GT)
  • alkaline phosphatase
  • serum globulin
  • serum albumin
  • prothrombin time
Todos los datos

Pruebas diagnósticas que deben considerarse

  • antinuclear antibodies (ANAs)
  • smooth muscle antibodies (SMAs)
  • anti-soluble liver antigens or liver/pancreas (anti-SLA/LP)
  • perinuclear antineutrophil cytoplasmic antibodies (pANCA)
  • antibodies against single-stranded DNA (anti-ssDNA)
  • antibodies against double-stranded DNA (anti-dsDNA)
  • antibodies to liver/kidney microsome type 1 antigen (anti-LKM-1)
  • antibodies to liver/kidney microsome type 3 antigen (anti-LKM-3)
  • antibodies to liver cytosol 1 antigen (anti-LC1)
  • antimitochondrial antibodies (AMAs)
  • antibodies against asialoglycoprotein receptor (anti-ASGP-R)
  • IgM antibodies to hepatitis A virus (IgM anti-HAV)
  • hepatitis B surface antigen (HBsAg)
  • antibodies to hepatitis B core antigen (anti-HBc)
  • hepatitis C antibodies and viral RNA
  • ceruloplasmin
  • alpha-1 antitrypsin
  • serum iron and total iron binding capacity
  • thiopurine methyltransferase (TPMT) activity
  • abdominal ultrasound
  • liver biopsy
Todos los datos

Pruebas emergentes

  • Transient elastography (TE)

Algoritmo de tratamiento

Inicial

acute severe disease

Agudo

active disease

inactive disease or minimally active disease with comorbidities

AIH-primary biliary cirrhosis overlap syndrome

En curso

inadequate response to initial therapy or single relapse: without hepatic decompensation

multiple previous relapses: without hepatic decompensation

decompensated liver disease

Colaboradores

Autores

George Y. Wu, MD, PhD
George Y. Wu

Professor Emeritus

Division of Gastroenterology - Hepatology

University of Connecticut School of Medicine

Farmington

CT

Divulgaciones

GYW presents lectures on autoimmune hepatitis nationally and internationally. He has acted as an expert witness for legal firms, is comprehensive editor in chief of the Journal of Clinical and Translational Hepatology, associate editor in chief of Medjaden, associate editor at the Journal of Digestive Diseases, and a book series editor for Springer-Nature, and a consultant in mitochondrial diseases at Mitrix Bio, Inc.

Roopjeet K. Bath, MBBS
Roopjeet K. Bath

Assistant Professor of Medicine

University of Connecticut School of Medicine

Farmington

CT

Divulgaciones

RKB declares that she has no competing interests.

Agradecimientos

Dr George Y. Wu and Dr Roopjeet K. Bath would like to gratefully acknowledge Dr Micheal Tadros, Dr Lucija Virovic Jukic, Dr Marcy L. Coash, and Dr Deepika Devuni, previous contributors to this topic. Dr Wu would also like to acknowledge the assistance of Dr Nathan Selky in the 2011 update.

Divulgaciones

MT, LVJ, MLC, and DD declare that they have no competing interests.

Revisores por pares

Kittichai Promrat, MD

Assistant Professor

Division of Gastroenterology

Department of Medicine

Brown University

RI

Divulgaciones

KP declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referencias

Nuestros equipos internos de evidencia y editoriales colaboran con colaboradores expertos internacionales y revisores pares para garantizar que brindemos acceso a la información más clínicamente relevante posible.

Artículos principales

Mack CL, Adams D, Assis DN, et al. Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases. Hepatology. 2020 Aug;72(2):671-722.Texto completo  Resumen

European Association for the Study of the Liver. EASL clinical practice guidelines: autoimmune hepatitis. J Hepatol. 2015 Oct;63(4):971-1004. Resumen

Gleeson D, Heneghan MA; British Society of Gastroenterology. British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis. Gut. 2011 Dec;60(12):1611-29.Texto completo  Resumen

Strassburg CP, Manns MP. Treatment of autoimmune hepatitis. Semin Liver Dis. 2009 Aug;29(3):273-85. Resumen

Selvarajah V, Montano-Loza AJ, Czaja AJ. Systematic review: managing suboptimal treatment responses in autoimmune hepatitis with conventional and nonstandard drugs. Aliment Pharmacol Ther. 2012 Oct;36(8):691-707.Texto completo  Resumen

Artículos de referencia

Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
  • Diferenciales

    • Primary biliary cirrhosis
    • Primary sclerosing cholangitis
    • Chronic hepatitis B
    Más Diferenciales
  • Guías de práctica clínica

    • ACR appropriateness criteria: abnormal liver function tests
    • Clinical practice guidelines: non-invasive tests for evaluation of liver disease severity and prognosis
    Más Guías de práctica clínica
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