Summary
定义
病史和体格检查
关键诊断因素
- fever
- malaise
- nausea and vomiting
- jaundice
- hepatomegaly
- right upper quadrant pain
- clay-colored stools
其他诊断因素
- fatigue
- headache
- dark urine
- pruritus
- arthralgias and myalgias
- cough
- diarrhea
- constipation
- splenomegaly
- posterior cervical lymphadenopathy
- evanescent rash
- bradycardia
危险因素
- living in endemic region
- travel to endemic region
- close personal contact with an infected person
- men who have sex with men
- known foodborne outbreak
- illegal drug use
- homelessness
- occupational exposure
诊断性检查
首要检查
- serum aminotransferases
- serum bilirubin
- BUN
- serum creatinine
- prothrombin time
- immunoglobulin M (IgM) antihepatitis A virus (HAV)
需考虑的检查
- immunoglobulin G (IgG) antihepatitis A virus (HAV)
- hepatitis A virus RNA detection
治疗流程
unvaccinated people with recent exposure to hepatitis A (<2 weeks)
confirmed hepatitis A
撰稿人
作者
Doan Y Dao, MD
Assistant Professor of Medicine
Director, Center of Excellence for Liver Disease in Vietnam
Johns Hopkins School of Medicine
Department of Medicine
Division of GI and Hepatology
Baltimore MD
利益声明
DYD receives grants from Roche Diagnostics International Ltd and Gilead Sciences.
鸣谢
Dr Doan Dao would like to gratefully acknowledge Dr Musaddiq Waheed and the late Dr Fida A. Khan, the previous contributors to this topic.
Disclosures
MW and FAK declared that they have no competing interests.
Peer reviewers
Howard J. Worman, MD
Professor of Medicine and Cell Biology
Columbia University College of Physicians and Surgeons
New York
NY
Disclosures
HJW declares that he has no competing interests.
Srikrishna Nagri, MD
Gastroenterologist
Dartmouth-Hitchcock Nashua
Nashua
NH
Disclosures
SN declares that he has no competing interests.
George Y. Wu, MD, PhD
Professor of Medicine
University of Connecticut Health Center
Farmington
CT
Divulgaciones
GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.
Kittichai Promrat, MD
Assistant Professor
Division of Gastroenterology
Department of Medicine
Brown University
RI
Divulgaciones
KP declares that he has no competing interests.
Pierre Van Damme, MD, PhD
Professor
Director of Vaccine & Infectious Disease Institute
University of Antwerp
Antwerp
Belgium
Divulgaciones
PVD has been and still is principal investigator of vaccine trials for several vaccine manufacturing companies, from which the university obtained and obtains research contracts and funds for conducting such vaccine trials.
Agradecimiento de los revisores por pares
Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.
Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Centers for Disease Control and Prevention. Hepatitis A. [internet publication].Texto completo
Kemmer NM, Miskovsky EP. Hepatitis A. Infect Dis Clin North Am. 2000 Sep;14(3):605-15. Resumen
Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
- Acute hepatitis B
- Hepatitis E
- Acute hepatitis C
Más DiferencialesGuías de práctica clínica
- Hepatitis A
- Child and adolescent immunization schedule by age: recommendations for ages 18 years or younger, United States, 2025
Más Guías de práctica clínica
Inicie sesión o suscríbase para acceder a todo el BMJ Best Practice
El uso de este contenido está sujeto a nuestra cláusula de exención de responsabilidad