Summary
Details
- Key highlights
- Algorithms and tables
- Indications for anticoagulation
- Indications: outcome event assessment
- Contraindications: absolute and relative contraindications
- Contraindications: bleeding risk assessment
- Initiating anticoagulation in primary care
- Initiating anticoagulation in acute inpatient care: initial therapy
- Initiating anticoagulation in acute inpatient care: transitioning to oral therapy
- Initiating anticoagulation in patients with HIT
- Warfarin initiation protocols
- Maintenance therapy: venous thromboembolism
- Maintenance therapy: atrial fibrillation
- Maintenance therapy: clinical re-evaluation
- Monitoring: general principles
- Monitoring: warfarin
- Monitoring: parenteral anticoagulants
- Monitoring: direct oral anticoagulants
- Surgery/procedure in anticoagulated patient: general principles
- Surgery/procedure in anticoagulated patient: management algorithm
- Special populations: pregnancy
- Special populations: breast-feeding
- Special populations: children
- Special populations: older patients
- Special populations: renal impairment
- Special populations: hepatic impairment
- Special populations: patients on antiplatelet therapy
- Complications: adverse effects
- Complications: bleeding
- Complications: management of bleeding
- Reversal agents: general principles
- Reversal agents: for heparins
- Reversal agents: for warfarin
- Reversal agents: for direct oral anticoagulants (DOACs)
- Anticoagulants: vitamin K antagonists
- Anticoagulants: oral direct thrombin inhibitors
- Anticoagulants: oral factor Xa inhibitors
- Anticoagulants: unfractionated heparin (UFH)
- Anticoagulants: low molecular weight heparins (LMWHs)
- Anticoagulants: parenteral factor Xa inhibitors
- Anticoagulants: heparinoids
- Anticoagulants: hirudins
- Anticoagulants: argatroban
- Patient information
- Guidelines
Contributors
Authors
Scott M. Stevens, MD
Thrombosis Clinic
Intermountain Medical Center
Murray
UT
Professor of Medicine
Department of Medicine
Intermountain Healthcare and University of Utah
Salt Lake City
UT
Disclosures
SMS declares that he has no competing interests.
Scott C. Woller, MD
Thrombosis Clinic
Intermountain Medical Center
Murray
UT
Professor of Medicine
Department of Medicine
Intermountain Healthcare and University of Utah
Salt Lake City
UT
Disclosures
SCW declares that he has no competing interests.
Gabriel V. Fontaine, PharmD, MBA, BCCCP, BCPS
Clinical Pharmacy Manager
Critical Care and Emergency Medicine
Advanced Clinical Pharmacist
Neuroscience Critical Care
Intermountain Medical Center
Murray
UT
Associate Professor
Intermountain Healthcare and University of Utah
Salt Lake City
UT
Disclosures
GVF has received speaking and consulting honoraria from Alexion Pharmaceuticals and AstraZeneca, and consulting honoraria from Anticoagulation Forum, Chiesi, and Marinus Pharmaceuticals.
Acknowledgements
Dr Scott M. Stevens, Dr Scott C. Woller, and Dr Gabriel V. Fontaine would like to gratefully acknowledge Erin Sage Chang, a previous contributor to this topic.
Disclosures
ESC declares that she has no competing interests.
Peer reviewers
Lori-Ann Linkins, MD, MSc(Clin Epi), FRCPC
Associate Professor
Department of Medicine
McMaster University
Thrombosis Consultant
Juravinski Hospital and Cancer Centre
Hamilton
Ontario
Canada
Disclosures
LL has been reimbursed for educational lectures for Pfizer Canada (Fragmin; dalteparin) and has received lecture honoraria and research funding from Bayer, Inc (Xarelto; rivaroxaban).
Scott Kaatz, DO, MSc, FACP, SFHM
Senior Staff Hospitalist
Medical Director for Professional Development and Research
Division of Hospital Medicine
Henry Ford Hospital
Detroit
MI
Disclosures
SK has received speaker honorarium from Janssen, Boehringer-Ingelheim, Bristol Myer Squibb/Pfizer, CSL Behring, and Daiichi Sankyo; he has served as a consultant for Boehringer-Ingelheim, Bristol Myer Squibb/Pfizer, Janssen, Daiichi Sankyo, and Portola; he also is a board member (non-profit) of the Thrombosis and Hemostasis Societies of North America, the AC Forum, the National Certification Board of Anticoagulation Providers, and the National Blood Clot Alliance Medical and Scientific Advisory Board.
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