Generalized anxiety disorder (GAD) is a common condition defined as chronic, excessive worry for at least 6 months that causes distress or impairment, and is hard to control.
At least three key symptoms out of a possible six are required to make a diagnosis of GAD in adults according to the Diagnostic and Statistical Manual of mental disorders, fifth edition, text revision (DSM-5-TR) criteria. These include restlessness or nervousness, being easily fatigued, poor concentration, irritability, muscle tension, and/or sleep disturbance. One key symptom is required to make the diagnosis in children.
It is in part a diagnosis of exclusion: physical health conditions, other mental health disorders, and medications or other substances should be ruled out as a primary cause.
Physical examination and laboratory studies are generally normal if no coexisting physical or mental health conditions or substance misuse issues exist.
Treatment is primarily with psychotherapy (usually cognitive behavioral therapy), serotonergic antidepressants, or a combination of these approaches.
Generalized anxiety disorder (GAD) is defined as at least 6 months of excessive worry about everyday issues that is disproportionate to any inherent risk, causing distress or impairment. The worry is not confined to features of another mental health disorder, a result of substance misuse, or relating only to a physical health condition. The worry is hard to control.
At least three of the following symptoms are present most of the time: restlessness or nervousness, being easily fatigued, poor concentration, irritability, muscle tension, or sleep disturbance. In children, at least one key symptom should be present most of the time.
Other common complaints are autonomic in nature, such as sweating, lightheadedness, palpitations, dizziness, and epigastric discomfort. Anxiety may be "free-floating" (i.e., not restricted to, or even strongly predominating in, any particular environmental circumstances). Examples of worries include fears that the patient or a relative will shortly become ill or have an accident.
History and exam
Key diagnostic factors
- excessive worry for at least 6 months
- anxiety not confined to another mental health disorder
- anxiety not due to medication or substance
- muscle tension
- sleep disturbance
- poor concentration
Other diagnostic factors
- gastrointestinal symptoms
- muscle aches
- increased heart rate
- shortness of breath
- exaggerated startle response
- chest pain
- family history of anxiety
- physical or emotional stress
- history of physical, sexual, or emotional trauma
- other anxiety disorder
- chronic physical health condition
- female sex
1st investigations to order
- clinical diagnosis
Investigations to consider
- thyroid function tests
- urine drug screen
- 24-hour urine for catecholamines, metanephrines, normetanephrines, and creatinine
- pulmonary function tests
anxiety symptoms meeting DSM-5-TR criteria
anxiety symptoms not meeting DSM-5-TR criteria
- Panic disorder
- Social anxiety disorder
- Obsessive-compulsive disorder
- Screening and diagnosis of mental health conditions during pregnancy and postpartum
- Treatment and management of mental health conditions during pregnancy and postpartum
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