Evaluation of inflamed joint

Last reviewed: 17 Apr 2022
Last updated: 12 Apr 2022

Summary

Differentials

Common

  • Septic nongonococcal arthritis
  • Gonococcal arthritis
  • Rheumatoid arthritis
  • Gout
  • Pseudogout
  • Psoriatic arthritis
Full details

Uncommon

  • Indolent infections
  • Parvoviral syndrome
  • Lyme disease
  • Juvenile idiopathic arthritis (oligo-articular type)
  • Acute rheumatic fever (ARF)
  • Sarcoidosis
  • Spondyloarthropathy
  • Systemic lupus erythematosus (SLE)
  • Adult-onset Still disease (AOSD)
  • Reactive arthritis
  • Ankylosing spondylitis (AS)
  • Osteoarthritis
  • Trauma
  • Nontraumatic hemarthrosis
  • Hypertrophic osteoarthropathy
  • Intra-articular metastatic cancer
  • Synovial sarcoma
  • Arbovirus infections (e.g., chikungunya)
  • Inflammatory bowel disease (ulcerative colitis and Crohn disease)
  • Celiac disease
  • Whipple disease
  • Bowel-associated dermatosis arthritis syndrome
  • Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome
  • Drug-induced
  • Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome
  • Ebola virus
  • Diffuse tenosynovial giant cell tumor (formerly, diffuse pigmented villonodular synovitis)
  • Localized tenosynovial giant cell tumor (formerly, localized pigmented villonodular synovitis)
  • Synovial osteochondromatosis
  • Amyloid arthropathy
  • Fibroblastic rheumatism
  • Multicentric reticulohistiocytosis (MRH)
Full details

Contributors

Authors

Soumya Chatterjee, MD, MS, FRCP(UK), FACP, FACR

Professor of Medicine

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University

Rheumatology Fellowship Program Director

Staff, Department of Rheumatic and Immunologic Diseases

Orthopedic and Rheumatologic Institute

Cleveland Clinic

Cleveland

OH

Disclosures

SC declares that he has no competing interests.

Peer reviewers

Hill Gaston, MA, PhD, BM BCh, FRCP, FMedSci

Professor of Rheumatology

University of Cambridge

Clinical Director

West Anglia CLRN

Cambridge

UK

Disclosures

HG declares that he has no competing interests.

Don L. Goldenberg, MD, FACP

Chief of Rheumatology

Director

Arthritis-Fibromyalgia Center

Newton-Wellesley Hospital

Newton

Professor of Medicine

Tufts University School of Medicine

Boston

MA

Disclosures

DLG declares that he has no competing interests.

Brent A. Ponce, MD

Associate Professor

Division of Orthopedic Surgery

University of Alabama

Birmingham

AL

Disclosures

BAP declares that he has no competing interests.

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