Fetal alcohol spectrum disorder

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თეორია 
დიაგნოზი 
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შედით სისტემაში ან გამოიწერეთ BMJ Best Practice

ბოლო მიმოხილვა: 17 Oct 2025

ბოლო განახლება: 20 Apr 2023

Fetal alcohol spectrum disorder (FASD) is considered a spectrum of disorders that includes FASD with and without sentinel facial features, fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorder, and alcohol-related birth defects.

Caused by fetal exposure to alcohol during pregnancy (prenatal alcohol exposure).

Early diagnosis may prevent secondary disabilities, but many clinicians are unaware of, or are confused by, existing diagnostic criteria and terminology.

Management involves identifying and working with a child's specific strengths and needs; however, there is a paucity of evidence for efficacy of specific treatments.

Prevention is a priority, as brain injury sustained in utero is permanent and is associated with severe physical, behavioral, learning, and mental health problems.

განსაზღვრება

Fetal alcohol spectrum disorder (FASD) refers to group of conditions that may result from fetal exposure to alcohol.[1] Disorders include fetal alcohol syndrome (FAS), partial FAS, alcohol-related neurodevelopmental disorder (ARND), alcohol-related birth defects (ARBD), and FASD with and without sentinel facial features. FAS is characterized by severe neurodevelopmental impairment, which may be associated with prenatal and postnatal growth retardation, specific facial dysmorphology, and structural abnormalities of the CNS. This topic primarily addresses FASD in children.

ანამნეზი და გასინჯვა

ძირითადი დიაგნოსტიკური ფაქტორები

gestation <37 weeks
low height, weight, head circumference
characteristic facial dysmorphology
presence of birth defects
developmental delay and behavioral problems
mental health problems
sibling with similar symptoms

სრული ტექსტი

სხვა დიაგნოსტიკური ფაქტორები

hearing or vision impairment
poor feeding
irritability

სრული ტექსტი

რისკფაქტორები

maternal alcohol intake during pregnancy
current maternal alcohol intake
higher parity/gravidity
higher birth order of child
maternal ADH1B*1/ADH1B*3 or ADH1B*1/ADH1B*1 genotype
longer history of maternal alcohol consumption
increasing maternal age
decreased maternal weight, height, and head circumference
maternal tobacco use during pregnancy
low maternal socioeconomic status
maternal family history of alcohol consumption
maternal Indigenous ethnicity

სრული ტექსტი

დიაგნოსტიკური კვლევები

1-ად შესაკვეთი გამოკვლევები

facial photographic assessment

სრული ტექსტი

გასათვალისწინებელი კვლევები

prenatal ultrasonography of fetus
ECG
echocardiogram
EEG
MRI/CT head
renal ultrasonography
skeletal x-ray
screening blood tests
chromosome microarray

სრული ტექსტი

ახალი ტესტები

functional MRI
magnetic resonance spectroscopy
3-dimensional facial imaging

მკურნალობის ალგორითმი

მიმდინარე

all patients

კონტრიბუტორები

ავტორები

Elizabeth Elliott, MD, MPhil, MBBS, FRACP, FRCPCH, FRCP

Professor of Paediatrics and Child Health

Faculty of Medicine and Health

University of Sydney

Consultant Paediatrician

The Children's Hospital at Westmead

Sydney

Director

Australian Paediatric Surveillance Unit

Head, New South Wales Fetal Alcohol Spectrum Disorder Assessment Servicer

Westmead

Australia

გაფრთხილება:

EE is an author of a number of references cited in this monograph but has no other competing interests.

მადლიერება

Professor Elizabeth Elliott would like to gratefully acknowledge Dr Elizabeth Peadon, a previous contributor to this monograph. EP is an author of a number of references cited in this monograph.

同行评议者

Albert E. Chudley, MD, FRCPC, FCCMG

Medical Director

Program in Genetics and Metabolism

Professor

Department of Pediatrics and Child Health

University of Manitoba

Winnipeg

Canada

利益声明

AEC has been paid an honorarium and consulting fees for the development of screening tools for identifying individuals at risk for FASD in Canada. AEC is an author of a number of references cited in this monograph.

Carol Bower, MD

Clinical Professor

Senior Principal Research Fellow

Telethon Institute for Child Health Research

Centre for Child Health Research

The University of Western Australia

Perth

Australia

利益声明

CB is an author of a number of references cited in this monograph, and sometimes collaborates with the authors.

Philip A. May, MD, PhD

Professor of Sociology

Professor of Family and Community Medicine

The University of New Mexico

Albuquerque

利益声明

PAM is an author of a number of references cited in this monograph.

Deborah Badawi, MD

Assistant Professor of Pediatrics

Division Head, Developmental-Behavioral Pediatrics

University of Maryland School of Medicine

Baltimore

Disclosures

DB declared no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Jones KL, Smith DW. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 1973 Nov 3;302(7836):999-1001. Abstract

Carson G, Cox LV, Crane J, et al.; Society of Obstetricians and Gynaecologists of Canada. Alcohol use and pregnancy consensus clinical guidelines. J Obstet Gynaecol Can. 2010 Aug;32(8 suppl 3):S1-31. Abstract

Astley SJ. Diagnostic guide for fetal alcohol spectrum disorders: the 4-digit diagnostic code. 3rd ed. Seattle, WA: University of Washington; 2004.Full text

Cook JL, Green CR, Lilley CM, et al. Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan. CMAJ. 2016 Feb 16;188(3):191-7.Full text Abstract

Streissguth AP, Bookstein FL, Barr HM, et al. Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. J Dev Behav Pediatr. 2004 Aug;25(4):228-38. Abstract

Koren G, Sarkar M, Rosenbaum C, et al. The maternal drinking history guide: development of a national educational tool. J Popul Ther Clin Pharmacol. 2013;20(1):e42-3. Abstract

Sarkar M, Burnett M, Carriere S, et al. Screening and recording of alcohol use among women of child-bearing age and pregnant women. Can J Clin Pharmacol. 2009 Winter;16(1):e242-63. Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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- Fetal hydantoin syndrome
- Fetal valproate syndrome
- Toluene embryopathy
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Guidelines
- Fetal alcohol spectrum disorders
- Children and young people exposed prenatally to alcohol: a national clinical guideline
More Guidelines
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ADHD: what is it?
Fetal alcohol spectrum disorders: what is it?
More Patient information
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Fetal alcohol spectrum disorder

შეჯამება

განსაზღვრება

ანამნეზი და გასინჯვა

ძირითადი დიაგნოსტიკური ფაქტორები

სხვა დიაგნოსტიკური ფაქტორები

რისკფაქტორები

დიაგნოსტიკური კვლევები

1-ად შესაკვეთი გამოკვლევები

გასათვალისწინებელი კვლევები

ახალი ტესტები

მკურნალობის ალგორითმი

all patients

კონტრიბუტორები

ავტორები

Elizabeth Elliott, MD, MPhil, MBBS, FRACP, FRCPCH, FRCP

გაფრთხილება:

მადლიერება

同行评议者

Albert E. Chudley, MD, FRCPC, FCCMG

利益声明

Carol Bower, MD

利益声明

Philip A. May, MD, PhD

利益声明

Deborah Badawi, MD

Disclosures

Peer reviewer acknowledgements

Disclosures

References

Key articles

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

Differentials

Guidelines

Patient information

Log in or subscribe to access all of BMJ Best Practice

Log in or subscribe to access all of BMJ Best Practice

Log in to access all of BMJ Best Practice