Last reviewed: June 2020
Last updated: March  2020

Summary

Differentials

Common

  • Hepatitis C virus infection
  • Hepatitis B virus infection
  • Hepatitis A virus infection
  • Alcohol-related liver disease
  • Acetaminophen overdose
  • Nonacetaminophen medications
  • Nonalcoholic fatty liver disease
  • Gilbert syndrome
  • Hemochromatosis
  • Choledocholithiasis

Uncommon

  • Hepatitis E
  • Hepatitis D
  • Epstein-Barr virus infection
  • Herpes simplex virus infection
  • Cytomegalovirus infection
  • HIV infection
  • Sepsis
  • Extrapulmonary tuberculosis
  • Toxins
  • Alpha-1 antitrypsin deficiency
  • Wilson disease
  • Autoimmune hepatitis
  • Primary biliary cholangitis
  • Primary sclerosing cholangitis
  • Hepatocellular carcinoma
  • Liver metastases
  • Pancreatic cancer
  • Cholangiocarcinoma
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Shock
  • Portal vein thrombosis
  • Budd-Chiari syndrome
  • Intrahepatic cholestasis of pregnancy
  • Hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome
  • Acute fatty liver of pregnancy

Contributors

Associate Professor

Department of Internal Medicine

TCU and UNTHSC School of Medicine

Medical Director of Liver Transplantation

Annette C. and Harold C. Simmons Transplant Institute

Baylor Scott & White All Saints Medical Center

Fort Worth

TX 

Disclosures

SAG declares that he has no competing interests.

Dr Stevan A. Gonzalez would like to gratefully acknowledge Dr Jeremy Cobbold, Dr William D. Carey, and Dr Achuthan Sourianarayanane, the previous contributors to this topic.

Peer reviewersVIEW ALL

Assistant Professor of Medicine

Director

Yale Viral Hepatitis Program

Section of Digestive Diseases

Yale School of Medicine

New Haven

CT

Disclosures

JKL declares that he has no competing interests.

Senior Lecturer in Hepatology & Honorary Consultant Physician

Liver Research Group

Institute of Biomedical Research

The Medical School

University of Birmingham

Birmingham

UK

Disclosures

PN declares that he has no competing interests.

Associate Professor of Medicine

Division of Digestive and Liver Diseases

University of Texas Southwestern Medical Center

Dallas

TX

Disclosures

MM is an author of a reference cited in this topic.

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