Thyroid function testing

Last reviewed: 28 Aug 2023
Last updated: 20 May 2020

Summary

Details

  • Thyroid hormone production
  • Thyroid hormone-binding proteins
  • Indications for TFTs: general considerations
  • Known thyroid dysfunction and preconception
  • Screening for thyroid dysfunction during pregnancy
  • TFTs
  • Low TSH - associated with a high FT4 and/or FT3
  • Low TSH - associated with a low FT4 and/or FT3
  • Low TSH - associated with a normal FT4 and/or FT3
  • High TSH - associated with a high FT4 and/or FT3
  • High TSH - associated with a low FT4 and/or FT3
  • High TSH - associated with a normal FT4 and/or FT3
  • Normal TSH - associated with a low FT4 and/or FT3
  • Drug effects
Full details

Contributors

Authors

Mae Sheikh-Ali, MD

Northeast Florida Endocrine & Diabetes Associates

Jacksonville

FL

Disclosures

MS-A declares that she is a speaker for Novo Nordisk, AstraZeneca, Amgen, Merck, Eli Lilly, Abbott, AbbVie, MannKind, Valeritas, and Janssen. MS-A declares that none of these are related to this topic.

Acknowledgements

Dr Mae Sheikh-Ali would like to gratefully acknowledge Dr Harshit Shah, Dr Melanie Thomas, Dr Anna Szafran-Swietlik, Dr Sandra Mesliniene, Dr Emad Naem, and Dr Abdul-Razzak Alamir, previous contributors to this topic. HS, MT, AS-S, SM, EN, and A-RA declare that they have no competing interests.

Peer reviewers

Ronald Merrell, MD

Professor of Surgery

Virginia Commonwealth University

Richmond

VA

Disclosures

RM declares that he has no competing interests.

Georg Hennemann, MD

Professor of Medicine and Endocrinology

Medical Center Spijkenisse

The Hague

The Netherlands

Disclosures

Not disclosed.

Simon Pearce, MD

Professor of Endocrinology

Newcastle University

Endocrine Unit

Royal Victoria Infirmary

Newcastle upon Tyne

UK

Disclosures

SP declares that he has no competing interests.

V.S. Schneider, MD

Clinical Associate Professor of Medicine

Uniformed Services University of the Health Sciences

Bethesda

MD

MA and Senior Medical Advisor

NASA Headquarters

Washington

DC

Disclosures

VSS declares that he has no competing interests.

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