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IgA vasculitis (Henoch-Schonlein purpura)

Last reviewed: 1 Apr 2025
Last updated: 08 Apr 2025

Summary

Definition

History and exam

Key diagnostic factors

  • rash
  • arthralgias
  • abdominal pain
  • signs of renal disease
Full details

Other diagnostic factors

  • drug history
  • scrotal pain or swelling
  • headaches
  • seizures
  • pulmonary hemorrhage
Full details

Risk factors

  • genetics
  • allergy
  • male sex
  • age 2 to 10 years
  • increasing age at onset
  • winter season/prior infection
  • medication
Full details

Diagnostic tests

1st tests to order

  • blood pressure
  • urinalysis
  • serum creatinine and electrolyte levels
Full details

Tests to consider

  • serum IgA levels
  • CBC and coagulation studies
  • skin biopsy
  • renal biopsy
  • ultrasound, abdomen
  • ultrasound, testicles
Full details

Treatment algorithm

ACUTE

without renal involvement

mild nephritis: normal GFR and mild or moderate proteinuria

moderate nephritis: <50% crescents on renal biopsy and impaired GFR or severe persistent proteinuria

severe nephritis: >50% crescents on renal biopsy and impaired GFR or severe persistent proteinuria

ONGOING

relapsed/refractory disease

Contributors

Authors

Louise Oni, MBChB, MRCPCH, MA, PhD

Senior Lecturer in Paediatric Nephrology and Honorary Consultant Paediatric Nephrologist

University of Liverpool

Department of Paediatric Nephrology

Alder Hey Children's NHS Foundation Trust Hospital

Liverpool

UK

Disclosures

In the past 12 months LO has contributed to expert advisory roles for Boehringer Ingelheim and Biocryst pharmaceuticals. LO has received a travel grant from Sandoz. These are unrelated to this article and all monetary payments are placed into an institutional educational charity account. LO is an author of references cited in this topic.

Peer reviewers

David Kershaw, MD

Professor of Pediatrics

University of Michigan

Ann Arbor

MI

Disclosures

DK is co-medical director for the board of directors of Nephcure.

Rajan Madhok, MD, FCRP

Consultant Physician and Rheumatologist

Centre for Rheumatic Diseases

Glasgow Royal Infirmary

Glasgow

UK

Disclosures

RM declares that he has no competing interests.

Richard A. Watts, MA, DM, FRCP

Consultant Rheumatologist

Ipswich Hospital NHS Trust

Ipswich

UK

Disclosures

RAW declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Ozen S, Marks SD, Brogan P, et al. European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis - the SHARE initiative. Rheumatology (Oxford). 2019 Sep 1;58(9):1607-16.Full text  Abstract

UK Kidney Association.​ The initial management of IgA vasculitis (Henoch Schönlein Purpura) in children and young people. Dec 2022 [internet publication].Full text

UK Kidney Association. The management of complications associated with IgA vasculitis (Henoch Schönlein Purpura) in children and young people. Dec 2022 [internet publication].Full text

Hahn D, Hodson EM, Craig JC. Interventions for preventing and treating kidney disease in IgA vasculitis. Cochrane Database Syst Rev. 2023 Feb 28;(2):CD005128.Full text  Abstract

Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int. 2021 Oct;100(4S):S1-276.Full text

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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