Last reviewed: September 2018
Last updated: July  2018

Summary

Differentials

Common

  • Carpal tunnel syndrome
  • Ulnar neuropathy
  • Fibular (peroneal) neuropathy
  • Meralgia paresthetica
  • Cervical radiculopathy
  • Thoracic radiculopathy
  • Lumbosacral radiculopathy
  • Spinal cord compression
  • Multiple sclerosis
  • Distal symmetric polyneuropathy (DSP)
  • Diabetes mellitus
  • Hypothyroidism
  • Vitamin B1 deficiency
  • Vitamin B6 deficiency or excess
  • Vitamin B12 deficiency
  • Vitamin E deficiency
  • Drug toxicity
  • Alcoholic neuropathy
  • Stroke/transient ischemic attack
  • Migraine with aura
  • Peripheral vascular disease
  • Panic attack with hyperventilation
  • Charcot-Marie-Tooth disease
  • Hereditary sensory and autonomic neuropathy (HSAN)
  • Hereditary neuropathy with liability to pressure palsy (HNPP)

Uncommon

  • Brachial plexopathy
  • Lumbosacral plexopathy
  • Tibial neuropathy
  • Trigeminal neuropathy
  • Acute demyelinating encephalomyelitis
  • Guillain-Barre syndrome
  • Chronic inflammatory demyelinating polyneuropathy (CIDP)
  • Chronic inflammatory demyelinating sensory polyradiculopathy (CISP)
  • Uremia
  • Hypocalcemia
  • Copper deficiency
  • Heavy metal poisoning
  • Radiation
  • Hexane
  • Ciguatera or saxitoxin poisoning
  • HIV neuropathy
  • Leprosy
  • Herpes simplex infection
  • Neurosyphilis
  • Herpes zoster infection (shingles)
  • Lyme disease
  • Conversion and somatization disorders
  • Inborn errors of metabolism
  • Rheumatoid arthritis
  • SLE
  • Churg-Strauss syndrome
  • Granulomatosis with polyangiitis (Wegener)
  • Polyarteritis nodosa
  • Microscopic polyangiitis
  • Sjogren syndrome
  • Sarcoidosis
  • Monoclonal protein production
  • Partial epilepsy
  • Paraneoplastic sensory neuropathy or ganglionopathy
  • Intravascular lymphoma
  • Neuro-Behcet disease
  • Wartenberg migrant sensory neuritis
  • Numb chin syndrome
  • Peripheral neuropathy after bariatric surgery
  • Notalgia paresthetica

Contributors

Authors VIEW ALL

We would like to gratefully acknowledge the late Dr Caroline M. Klein for her contribution to this topic.

Disclosures

CMK authored a number of references cited in this topic.

Peer reviewers VIEW ALL

Director

Neuromuscular Diagnostic Laboratory

Associate Professor

Department of Neurology

ALS and Neuromuscular Center

University of California

Irvine

CA

Disclosures

AW declares that she has no competing interests.

Assistant Professor of Neurosciences

Hotchkiss Brain Institute

University of Calgary

Alberta

Canada

Disclosures

CT declares that he has no competing interests.

Senior Lecturer and Consultant Neurologist

Department of Clinical Neuroscience

UCL Institute of Neurology

London

UK

Disclosures

RWO declares that he has no competing interests.

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