Takayasu arteritis

Last reviewed: 23 Aug 2023
Last updated: 22 Jun 2023



History and exam

Key diagnostic factors

  • upper or lower limb claudication
  • absent pulse(s)
  • unequal blood pressures
  • vascular bruits
  • low-grade fever
More key diagnostic factors

Other diagnostic factors

  • transient ischemic attack (TIA)
  • myalgia
  • arthralgia
  • weight loss
  • fatigue
  • dizziness on upper-limb exertion
  • hypertension
  • stroke
  • chest pain
  • abdominal pain
  • diarrhea
  • shortness of breath
  • hemoptysis
  • night sweats
  • vertigo
  • syncope
  • headache
  • heart murmur
  • visual symptoms
  • erythema nodosum
  • pyoderma gangrenosum
Other diagnostic factors

Risk factors

  • genetic predisposition
  • female sex
  • age <40 years
  • Asian ethnicity
More risk factors

Diagnostic investigations

1st investigations to order

  • erythrocyte sedimentation rate (ESR)
  • C-reactive protein (CRP)
  • computed tomography angiography (CTA)
  • magnetic resonance angiography (MRA)
More 1st investigations to order

Investigations to consider

  • Doppler ultrasound
  • positron emission tomography with radiolabeled fluorodeoxyglucose (PET-FDG)
More investigations to consider

Treatment algorithm


all patients



Kenneth J. Warrington, MD
Kenneth J. Warrington

Professor of Medicine

Mayo Clinic College of Medicine




KJW declares that he has received clinical trial support from Eli Lilly, GSK, and Kiniksa. He has received consulting fees and honoraria from Chemocentryx. KJW is an author of a number of references cited in this topic.


Dr Kenneth J. Warrington would like to gratefully acknowledge Dr Steven R. Ytterberg and Dr Eric L. Matteson, previous contributors to this topic.


SRY declares that he was a sub-awardee of a grant from the US Food and Drug Administration for a pilot study of abatacept, a treatment for Takayasu arteritis. SRY is also a member of the steering committee at the Vasculitis Clinical Research Committee. ELM declares that he has no competing interests.

Peer reviewers

Loic P. Guillevin, MD

Internal Medicine

Hopital Cochin-Paris University





LPG declares that he has no competing interests.

Gene G. Hunder, MD

Department of Medicine

Division of Rheumatology

Mayo Clinic




GGH is an author of a reference cited in this topic. GGH declares that he has no other competing interests.

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