Systemic candidiasis is an infection of blood or other normally sterile site with Candida species.
Major risk factors are use of central venous catheters, exposure to broad-spectrum antibiotics, and neutropenia.
Blood cultures are only 70% to 80% sensitive in diagnosis.
Therapy should be started within 24 hours of diagnosis to improve outcome. An echinocandin is first-line choice; fluconazole may be considered in certain circumstances.
Central venous catheters should be removed in non-neutropenic patients.
Ophthalmologic exam is recommended for all patients with candidemia.
Systemic candidiasis (acute disseminated candidiasis) is an infection of blood or other normally sterile site (e.g., pleural and peritoneal fluid) with Candida species, usually in association with fever, hypotension, and/or leukocytosis.Candidemia, or bloodstream infection, is the most common form of systemic candidiasis. However, Candida organisms may be disseminated to multiple sites, notably retina, kidney, liver and spleen, bones, and the central nervous system. Chronic disseminated candidiasis usually implies involvement of liver and/or spleen in association with recovery from chemotherapy-induced neutropenia.
History and exam
Key diagnostic factors
Other diagnostic factors
- poor capillary refill
- acute mental confusion
- decreased urine output
- low oxygen saturation
- use of central venous catheter
- exposure to broad-spectrum antibiotics
- parenteral nutrition
- immunosuppressants (e.g., chemotherapy, systemic corticosteroids, biologic and other immunosuppressants)
- colonization at multiple sites
- intravenous drug use
1st investigations to order
- blood culture
- lactate levels
- coagulation studies
- renal function tests
- liver function test
- serum glucose
Investigations to consider
- T2 magnetic resonance assay
- tissue biopsy
- polymerase chain reaction
- matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry
confirmed diagnosis: non-neutropenic patients (no complications)
confirmed diagnosis: neutropenic patients (no complications)
confirmed diagnosis: with complications
- Bacterial sepsis
- Drug-induced fever
- Pulmonary embolism
- Revision and update of the consensus definitions of invasive fungal disease
- Clinical practice guideline for the management of candidiasis
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