შეჯამება
განსაზღვრება
ანამნეზი და გასინჯვა
ძირითადი დიაგნოსტიკური ფაქტორები
- fever
სხვა დიაგნოსტიკური ფაქტორები
- tachycardia
- tachypnea
- hypotension
- poor capillary refill
- acute mental confusion
- decreased urine output
- low oxygen saturation
- rash
- hepatosplenomegaly
- hypothermia
რისკფაქტორები
- use of central venous catheter
- exposure to broad-spectrum antibiotics
- hemodialysis
- surgery
- parenteral nutrition
- immunosuppressants (e.g., chemotherapy, systemic corticosteroids, biologic and other immunosuppressants)
- colonization at multiple sites
- intravenous drug use
დიაგნოსტიკური კვლევები
1-ად შესაკვეთი გამოკვლევები
- blood culture
- CBC
- ABG
- lactate levels
- coagulation studies
- renal function tests
- liver function test
- serum glucose
გასათვალისწინებელი კვლევები
- 1,3-beta-D-glucan
- T2 magnetic resonance assay
- tissue biopsy
ახალი ტესტები
- polymerase chain reaction
- matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry
მკურნალობის ალგორითმი
suspected diagnosis
confirmed diagnosis: non-neutropenic patients (no complications)
confirmed diagnosis: neutropenic patients (no complications)
confirmed diagnosis: with complications
კონტრიბუტორები
ავტორები
Brenda L. Tesini, MD
Assistant Professor
Infectious Diseases
Departments of Medicine and Pediatrics
University of Rochester Medical Center
Rochester
NY
გაფრთხილება:
BLT has received honoraria from Merck for educational contributions unrelated to this topic.
მადლიერება
Dr Brenda L. Tesini would like to gratefully acknowledge Dr Jack D. Sobel and Dr Sanjay G. Revankar, previous contributors to this topic.
გაფრთხილება:
JDS declares that he has no competing interests. SR has received grants for research from Astellas, Gilead, and Merck, and has been involved in clinical trials for Cidara and Astellas.
რეცენზენტები
John Fisher, MD
Professor of Medicine
Department of Medicine
Medical College of Georgia
Augusta
GA
გაფრთხილება:
JF is an author of a number of references cited in this topic. JF is a member of the speaker's bureau for the following companies: Pfizer, Merck, and Astellas.
Jean-Michel Livrozet, MD
Praticien hospitalier
Service de medecine de la Transplantation et d'Immunologie clinique
Hopital Edouard Herriot
Lyon
France
利益声明
JML has been invited by Astellas, the manufacturer of micafungin, to attend a symposium, and invited by Gilead Sciences, manufacturer of liposomal amphotericin B, to attend different HIV conferences, and has been paid by Gilead Sciences for running HIV educational programs.
Matthew Falagas, MD, MSc, DSc
Director
Alfa Institute of Biomedical Sciences
Marousi
Athens
Greece
利益声明
MF declares that he has no competing interests.
参考文献
关键文献
Tsay SV, Mu Y, Williams S, et al. Burden of candidemia in the United States, 2017. Clin Infect Dis. 2020 Dec 3;71(9):e449-53.全文 摘要
Centers for Disease Control and Prevention. Candida auris: information for laboratorians and health professionals. Jul 2021 [internet publication].全文
Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Feb 15;62(4):e1-50.全文 摘要
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
鉴别诊断
- Bacterial sepsis
- Drug-induced fever
- Pulmonary embolism
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- Revision and update of the consensus definitions of invasive fungal disease
- Clinical practice guideline for the management of candidiasis
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