Hypogammaglobulinemia can be primary (congenital) or secondary. It can present in childhood and in adults, and can affect both sexes.
Primary hypogammaglobulinemia (most common cause being common variable immunodeficiency [CVID]) may have a delay of several years between clinical presentation and diagnosis.
Causes of secondary hypogammaglobulinemia include gastrointestinal losses (e.g., malabsorption/protein-losing enteropathy), nephrotic syndrome, hematologic malignancy, and medication (e.g., immunosuppressives, such as corticosteroids and chemotherapy).
Patients can be predisposed to recurrent upper and lower respiratory tract infections.
Treatment is tailored to specific causes and the clinical presentation of each patient, and includes intravenous or subcutaneous immunoglobulin replacement.
Severe combined immunodeficiency (SCID) is a medical emergency and suspected cases require immediate specialist center referral for diagnosis and treatment.
Hypogammaglobulinemia is defined as reduced serum immunoglobulin (antibody) levels. This can be due to a variety of underlying primary/congenital intrinsic immune system defects (e.g., common variable immunodeficiency) or secondary immunodeficient states (e.g., medication-related, hematologic malignancy, protein-losing diseases). The most commonly recognized clinical feature is recurrent infection.
History and exam
- absence from school/work
- failure to thrive
- tympanic membrane perforation
- illness after live vaccines
- weight loss, night sweats, fevers
- alopecia, goiter, vitiligo
- small/absent tonsils
- lymphadenopathy and hepatosplenomegaly
- history of celiac disease or transfusion reactions
- muscle fatigability, ptosis, diplopia (if thymoma present)
- dysmorphic features
- neurologic involvement
- flow cytometry: lymphocyte subsets
- specific antimicrobial antibodies
- test immunization response
- IgG subclasses
- flow cytometry: protein expression
- genetic testing
- enzyme assays
- abdominal ultrasound
- CT chest/sinuses
- CT abdomen
- lymph node biopsy
- small- and large-bowel biopsy
- polymerase chain reaction (PCR) for viral infection
- HBsAg, hepatitis B and C PCR
Allergy and Clinical Immunology Unit
Division of Rheumatology, Allergy & Immunology
Massachusetts General Hospital
SB is an author of one reference cited in this topic. SB declares that she has no competing interests.
Dr Sara Barmettler would like to gratefully acknowledge Dr Mohammed Yousuf Karim, Dr Patrick Yong, and Dr Zoe Adhya, previous contributors to this topic.
MYK serves on the advisory board for Allergy Therapeutics. PY and ZA declare that they have no competing interests.
Associate Professor of Pediatrics
University of New South Wales
Department of Immunology and Infectious Diseases
Sydney Children's Hospital
JBZ declares that he has no competing interests.
Professor of Medicine and Pediatrics
Mount Sinai School of Medicine
CCR is an author of several references cited in this topic.
Honorary Clinical Scientist
UCL Centre for Primary Immunodeficiency
University College London Medical School
Department of Immunology
Royal Free Hospital
DW declares that he has no competing interests.
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