Last reviewed: 4 Feb 2021
Last updated: 07 Dec 2018
Summary
Definition
History and exam
Key diagnostic factors
- splenomegaly
- malaise
- night sweats
- fever
- excessive bleeding
- bone pain
Other diagnostic factors
- weight loss
- petechiae, ecchymoses, or easy bruising
- infection
- abdominal pain
- visual changes
- focal neurologic signs
- priapism
- confusion or stupor
Risk factors
- history of chronic myelogenous leukemia (CML)
- exposure to ionizing radiation
- exposure to alkylating chemotherapeutic agents
Diagnostic investigations
Investigations to consider
- peripheral blood smear
- bone marrow aspiration and biopsy
- karyotype
- fluorescent in situ hybridization
- quantitative PCR
- serum leukocyte alkaline phosphatase
- serum vitamin B12
- T315I gene mutation test
Treatment algorithm
Contributors
Authors

Professor of Medicine
University of Florida College of Medicine
Jacksonville
FL
Disclosures
CP declares that he has no competing interests.
Associate Professor of Medicine
University of Florida College of Medicine
Jacksonville
FL
Disclosures
FR declares that she has no competing interests.
Peer reviewers
Assistant Professor of Human Cancer Genetics
Ohio State University
Columbus
OH
Disclosures
DP declares that he has no competing interests.
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