Last reviewed:September 2019
Last updated:December  2018

Summary

Definition

History and exam

Key diagnostic factors

  • splenomegaly
  • malaise
  • night sweats
  • fever
  • excessive bleeding
  • bone pain

Other diagnostic factors

  • weight loss
  • petechiae, ecchymoses, or easy bruising
  • infection
  • abdominal pain
  • visual changes
  • focal neurological signs
  • priapism
  • confusion or stupor

Risk factors

  • history of chronic myelogenous leukaemia (CML)
  • exposure to ionising radiation
  • exposure to alkylating chemotherapeutic agents

Diagnostic investigations

Investigations to consider

  • peripheral blood smear
  • bone marrow aspiration and biopsy
  • karyotype
  • fluorescent in situ hybridisation
  • quantitative PCR
  • serum leukocyte alkaline phosphatase
  • serum vitamin B12
  • T315I gene mutation test
Full details

Treatment algorithm

Contributors

Carlos Palacio

Professor of Medicine

University of Florida College of Medicine

Jacksonville

FL

Disclosures

CP declares that he has no competing interests.

Associate Professor of Medicine

University of Florida College of Medicine

Jacksonville

FL

Disclosures

FR declares that she has no competing interests.

Peer reviewersVIEW ALL

Assistant Professor of Human Cancer Genetics

Ohio State University

Columbus

OH

Disclosures

DP declares that he has no competing interests.

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