Summary
Differentials
Common
- Infection
- Inflammatory conditions
- Chronic myeloid leukemia (CML)
- Essential thrombocythemia
- Polycythemia vera
- Primary myelofibrosis
- Pregnancy
Uncommon
- Platelet clumping
- Cryoglobulinemia
- Anemia
- Solid tumor malignancy
- Bone marrow infiltration
- Heat stroke
- Chronic bone marrow stimulation
- Asplenia
- Sweet syndrome
- Drug-induced hematopoiesis
- Chronic neutrophilic leukemia
- Myelodysplastic syndrome
- Acute myeloid leukemia
- Hereditary neutrophilia
- Pelger-Huet abnormality
- Amegakaryocytic thrombocytopenia
- Trisomy 21 (Down syndrome)
- Leukocyte adhesion deficiency type I
- Familial cold autoinflammatory syndrome
- Chronic idiopathic neutrophilia
- Stress-induced demargination
- Drug-induced demargination
- Drug-induced decreased egress
Contributors
Authors
Devon Chabot-Richards, MD
Professor of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
DCR declares that she is a board member for New Mexico Society for Clinical Oncology, and lectures and takes part in educational events for the College of American Pathologists. She receives royalties from Elsevier.
Tracy I. George, MD
Professor of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
TIG declares that she has no competing interests.
Acknowledgements
Dr Devon Chabot-Richards and Dr Tracy I. George would like to gratefully acknowledge Dr Holbrook Kohrt, a previous contributor to this topic.
Disclosures
HK declares that he has no competing interests.
Peer reviewers
Carla Wilson, MD, PhD
Professor
Department of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
CW declares that she has no competing interests.
Sherrie Perkins, MD, PhD
Professor of Pathology
Medical Director of Hematopathology
University of Utah Health Sciences and ARUP Laboratories
Salt Lake City
UT
Disclosures
SP declares that she has no competing interests.
John Reilly, BSc, MD, FRCP, FRCPath
Consultant Haematologist
Royal Hallamshire Hospital
Professor
University of Sheffield
Sheffield
UK
Disclosures
JR declares that he has no competing interests.
Priyanka Mehta, MD, MRCP, FRCPath
Consultant Haematologist
University Hospital Bristol
Bristol
UK
Disclosures
PM declares that she has no competing interests.
References
Key articles
Hoffman R, Benz E, Silberstein L, et al. Hematology basic principles and practice. 7th ed. Philadelphia, PA: Elsevier Churchill Livingston; 2017.
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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