Evaluation of neutrophilia

Last reviewed: 3 May 2025
Last updated: 23 May 2025

Summary

Differentials

Common

  • Infection
  • Inflammatory conditions
  • Chronic myeloid leukemia (CML)
  • Essential thrombocythemia
  • Polycythemia vera
  • Primary myelofibrosis
  • Pregnancy
Full details

Uncommon

  • Platelet clumping
  • Cryoglobulinemia
  • Anemia
  • Solid tumor malignancy
  • Bone marrow infiltration
  • Heat stroke
  • Chronic bone marrow stimulation
  • Asplenia
  • Sweet syndrome
  • Drug-induced hematopoiesis
  • Chronic neutrophilic leukemia
  • Myelodysplastic syndrome
  • Acute myeloid leukemia
  • Hereditary neutrophilia
  • Pelger-Huet abnormality
  • Amegakaryocytic thrombocytopenia
  • Trisomy 21 (Down syndrome)
  • Leukocyte adhesion deficiency type I
  • Familial cold autoinflammatory syndrome
  • Chronic idiopathic neutrophilia
  • Stress-induced demargination
  • Drug-induced demargination
  • Drug-induced decreased egress
Full details

Contributors

Authors

Devon Chabot-Richards, MD

Professor of Pathology

University of New Mexico Health Sciences Center

Albuquerque

NM

Disclosures

DCR declares that she is a board member for New Mexico Society for Clinical Oncology, and lectures and takes part in educational events for the College of American Pathologists. She receives royalties from Elsevier.

Tracy I. George, MD

Professor of Pathology

University of New Mexico Health Sciences Center

Albuquerque

NM

Disclosures

TIG declares that she has no competing interests.

Acknowledgements

Dr Devon Chabot-Richards and Dr Tracy I. George would like to gratefully acknowledge Dr Holbrook Kohrt, a previous contributor to this topic.

Disclosures

HK declares that he has no competing interests.

Peer reviewers

Carla Wilson, MD, PhD

Professor

Department of Pathology

University of New Mexico Health Sciences Center

Albuquerque

NM

Disclosures

CW declares that she has no competing interests.

Sherrie Perkins, MD, PhD

Professor of Pathology

Medical Director of Hematopathology

University of Utah Health Sciences and ARUP Laboratories

Salt Lake City

UT

Disclosures

SP declares that she has no competing interests.

John Reilly, BSc, MD, FRCP, FRCPath

Consultant Haematologist

Royal Hallamshire Hospital

Professor

University of Sheffield

Sheffield

UK

Disclosures

JR declares that he has no competing interests.

Priyanka Mehta, MD, MRCP, FRCPath

Consultant Haematologist

University Hospital Bristol

Bristol

UK

Disclosures

PM declares that she has no competing interests.

References

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Key articles

Hoffman R, Benz E, Silberstein L, et al. Hematology basic principles and practice. 7th ed. Philadelphia, PA: Elsevier Churchill Livingston; 2017.

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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