Affects millions of travelers worldwide.
Rapid change in time zone produces a constellation of symptoms called jet lag disorder.
Symptoms include difficulty initiating and maintaining sleep, reduced daytime alertness, general malaise, and gastrointestinal symptoms.
Severity of symptoms depends on the number of time zones crossed, times of travel, quality of sleep in flight, circadian time cues at the place of travel, individual propensity, and direction of travel.
A temporary condition; symptoms are self-limited. Treatments include melatonin and alteration of light exposure.
This topic focuses on jet lag. Jet lag disorder is a temporary desynchronization between endogenous body rhythms and exogenous environmental rhythms, caused by rapid transmeridian travel across different time zones, leading to sleep disturbance, reduced alertness, general malaise, and gastrointestinal symptoms. 
Sleep Disorders Center
Department of Neurology
AA declares that he has no competing interests.
Dr Ashish Adlakha would like to gratefully acknowledge Dr Sudhansu Chokroverty, a previous contributor to this topic.
Johns Hopkins Sleep Disorders Center
DNN has received consulting fees and honoraria for speaking programs from Sanofi-Aventis and Takeda Pharmaceuticals. These companies manufacture medications mentioned in this topic.
UK Cochrane Centre
AH is an author of a number of references cited in this topic.
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