Rare disease associated with jaundice, coagulopathy, and hepatic encephalopathy.
The etiology and the interval from onset of jaundice to the development of encephalopathy have a significant impact on prognosis.
Etiology is established by history, serological assays, and exclusion of alternative causes, including acute presentations of chronic liver diseases.
Treatment involves ICU monitoring, specific therapies based on etiology, and management of known complications.
All patients should be considered for possible liver transplantation.
Prognostic models may be used to assess the probability of spontaneous recovery and are instrumental in selection of patients who should potentially undergo liver transplantation.
Acute liver failure (ALF) is a rare syndrome defined by a rapid decline in hepatic function characterized by jaundice, coagulopathy (INR >1.5), and hepatic encephalopathy in patients with no evidence of prior liver disease.    The interval from the onset of jaundice to the development of encephalopathy occurs within 24 to 26 weeks and may further classify ALF into categories based on hyperacute, acute, or subacute presentations.  Although clinical jaundice is considered a defining feature of ALF, it may not always be present, particularly in hyperacute presentations. The term acute liver failure is preferred over fulminant hepatic failure or acute hepatic necrosis, although these terms have been used historically to classify hepatic failure.   
Clinical Assistant Professor
Department of Internal Medicine
Texas A&M College of Medicine
Medical Director of Liver Transplantation
Annette C. and Harold C. Simmons Transplant Institute
Baylor All Saints Medical Center
SAG declares that he has no competing interests.
Dr Stevan Gonzalez would like to gratefully acknowledge the late Dr Emmet B. Keeffe who previously co-contributed to this monograph; an esteemed colleague, friend, and mentor. EBK declared that he had no competing interests.
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