Chaotic and irregular atrial arrhythmia, the prevalence of which increases progressively with age.
Patients frequently have coexisting cardiac or noncardiac conditions, such as hypertension, coronary artery disease, valvular disease, heart failure, obesity, and sleep apnea or pulmonary disease.
Causes significant morbidity (e.g., palpitations, dyspnea, angina, dizziness or syncope, and features of heart failure, tachycardia-induced cardiomyopathy, or stroke) and death. Many patients are asymptomatic or have symptoms that are less specific for cardiac arrhythmias, such as mild dementia or silent strokes.
ECG shows absent P waves, presence of fibrillatory waves, and irregularly irregular QRS complexes.
Treatment strategy depends on the severity of symptoms, the duration of AF, and the presence of comorbid conditions. Treatment involves correction of the abnormal rate, or rate plus rhythm, along with anticoagulation in high-risk patients.
Risks and benefits of a chosen therapy, such as rate control or rhythm control strategies utilizing beta-blockers, calcium blockers, digoxin, anti-arrhythmic agents, catheter-based or surgical ablation for pulmonary vein isolation and left atrial substrate modification, pacemakers, and ablation of the atrioventricular node need to be weighed based on multiple clinical factors to optimize patient outcome.
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia. It is characterized by uncoordinated atrial activity on the surface ECG, with fibrillatory waves of varying shapes, amplitudes, and timing associated with an irregularly irregular ventricular response when atrioventricular conduction is intact.
History and exam
- coronary artery disease
- congestive heart failure
- advancing age
- diabetes mellitus
- rheumatic valvular disease
- alcohol abuse
- male sex
- presence of other arrhythmias
- thyroid disease
- autonomic neuronal dysfunction
- obesity and obstructive sleep apnea (OSA)
- caffeine abuse
- working long hours
Assistant Professor of Medicine
Mount Sinai School of Medicine
ANS declares that she has no competing interests.
President, Cardiovascular and Heart Rhythm Consultants
Clinical Professor of Medicine
Icahn School of Medicine at Mount Sinai
Attending and Consultant Cardiac Electrophysiologist
Mount Sinai and New York Presbyterian Hospitals
BKK declares that he has no competing interests.
Jersey General Hospital
ARJM declares that he has no competing interests.
Professor of Medicine (Cardiology)
Westchester Medical Center
DJ declares that he has no competing interests.
Department of Cardiothoracic Surgery
Mount Sinai Medical Center
KP declares that he has no competing interests.
2018 joint European consensus document on the management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous cardiovascular interventions external link opens in a new windowMore guidelines
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