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Short bowel syndrome

Last reviewed: 5 Aug 2025
Last updated: 29 Jun 2022

Summary

Definition

History and exam

Key diagnostic factors

  • weight loss
  • diarrhea
  • volume depletion
  • peripheral or presacral edema
Full details

Other diagnostic factors

  • fatigue
  • postprandial epigastric or right upper quadrant abdominal pain
  • dysuria or renal colic
  • abnormal neurologic examination
  • jaundice and pruritus
  • dermatologic signs
  • night blindness
  • motor weakness or altered gait
  • proximal muscle weakness
  • excessive bleeding
  • confusion
Full details

Risk factors

  • bowel resection
  • extensive abdominal radiation injury
  • gastroschisis
Full details

Diagnostic tests

1st tests to order

  • CBC
  • serum electrolytes
  • BUN and creatinine
  • serum albumin
  • serum calcium, zinc, selenium, folate
  • vitamins A, B1, B2, B6, B12, C, D, and E
  • methylmalonic acid (MMA)
  • INR
Full details

Tests to consider

  • serum hepatic aminotransferases, alkaline phosphatase, and bilirubin (total and direct)
  • urine analysis
  • serum D-lactate
  • fecal fat quantification
  • upper gastrointestinal contrast series
  • Dual-energy x-ray absorptiometry (DXA) scan
  • abdominal ultrasound
  • CT abdomen
Full details

Treatment algorithm

ACUTE

jejunoileocolic anastomosis

jejunoileal anastomosis with fully resected colon

end jejunostomy or duodenostomy

ONGOING

all patients

Contributors

Authors

Alan Buchman, MD, MSPH, FACP, FACG, FACN, AGAF
Alan Buchman

Medical Director, Gastroenterology

Anthem Health

Indianapolis

IN

Disclosures

AB is an author of references cited in this topic.

Acknowledgements

Dr Alan Buchman would like to gratefully acknowledge Dr Michael Roth, a previous contributor to this topic. MR is an author of a reference cited in this topic.

Revisores

Marian F. Winkler, PhD RD

Professor of Surgery

Surgical Nutrition Specialist

Alpert Medical School of Brown University and Rhode Island Hospital

Providence

RI

Declarações

MFW declares that she has no competing interests.

Jonathan Shaffer, MBBS

Hospital Dean

Intestinal Failure Unit

Hope Hospital

Salford

Manchester

UK

Declarações

Not disclosed. JS is the author of references cited in this topic.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Pironi L, Arends J, Baxter J, et al. ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clin Nutr. 2015 Apr;34(2):171-80.Texto completo  Resumo

Cuerda C, Pironi L, Arends J, et al. ESPEN practical guideline: clinical nutrition in chronic intestinal failure. Clin Nutr. 2021 Sep;40(9):5196-220.Texto completo  Resumo

Buchman AL. Short bowel syndrome. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. 11th ed. Philadelphia, PA: Saunders; 2020.

Buchman AL, Scolapio J, Fryer J. AGA technical review on short bowel syndrome and intestinal transplantation. Gastroenterology. 2003 Apr;124(4):1111-34.Texto completo  Resumo

Nightingale JM, Lennard-Jones JE, Gertner DJ, et al. Colonic preservation reduces need for parenteral therapy, increases incidence of renal stones, but does not change high prevalence of gallstones in patients with a short bowel. Gut. 1992 Nov;33(11):1493-7. Resumo

Artigos de referência

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  • Diagnósticos diferenciais

    • Active Crohn disease
    • Celiac disease
    • Small bowel malignancy
    Mais Diagnósticos diferenciais
  • Diretrizes

    • ESPEN guidelines on clinical nutrition in chronic intestinal failure
    • ESPEN guidelines on home parenteral nutrition
    Mais Diretrizes
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