Summary
Definition
History and exam
Key diagnostic factors
- hematuria (visible or nonvisible)
Other diagnostic factors
- urinary frequency
- dysuria
Risk factors
- tobacco exposure
- exposure to chemical carcinogens
- age >65 years
- pelvic radiation
- cyclophosphamide use
- Schistosoma infection
- male sex
- chronic bladder inflammation
- genetic predisposition
- diabetes mellitus
Diagnostic tests
1st tests to order
- urinalysis
Tests to consider
- cystoscopy
- urine cytology
- CT urogram
- MR urogram
- renal and bladder ultrasound
- CBC
- chemistry profile (including alkaline phosphatase)
- chest x-ray
- CT abdomen and pelvis
- MRI abdomen and pelvis
- fluorodeoxyglucose (FDG)-PET/CT
- bone scan
- urine biomarkers
Algoritmo de tratamiento
nonmuscle-invasive tumors
locally invasive tumors
metastatic disease
Colaboradores
Autores
Joshua J. Meeks, MD, PhD
Associate Professor of Urology
Northwestern University Feinberg School of Medicine
Chicago
IL
Divulgaciones
JJM is a consultant for Merck, AstraZeneca, Incyte, Janssen, BMS, UroGen, Prokarium, Imvax, Pfizer, and Seagen/Astellas. He has received research funding from the VHA, NIH, and DoD; compensation for talks/educational courses from the AUA, OncLive, Olympus, and UroToday; and clinical trial support from SWOG, Genentech, Merck, AstraZeneca, and Incyte. JJM holds patents on T1 and TCGA classifiers; these are not currently available for use in clinical practice. JJM is an author of a reference cited in this topic.
David VanderWeele, MD, PhD
Associate Professor, Hematology and Oncology
Northwestern University Feinberg School of Medicine
Chicago
IL
Divulgaciones
DVW declares that he has received payments from Clovis Oncology, Exelixis, Janssen, and Bayer for advisory boards; research payments from AstraZeneca for clinical trials; payments from Astellas and Myovant for lectures; and payments from Exelixis and AstraZeneca for travel and dinner costs.
Sarah E. Fenton, MD, PhD
Assistant Professor, Hematology and Oncology
Northwestern University Feinberg School of Medicine
Chicago
IL
Divulgaciones
SEF declares that she has no competing interests.
Agradecimientos
Dr Joshua J. Meeks, Dr David VanderWeele, and Dr Sarah E. Fenton would like to gratefully acknowledge Dr Donald Lamm and Dr Mary Heeley, previous contributors to this topic.
Divulgaciones
DL is an author of a number of references cited in this topic. MH declares that she has no competing interests.
Revisores por pares
Junaid Masood, MBBS, FRCS (Eng), MSc (Urol), FRCS (Urol)
Consultant Urological Surgeon
Homerton University Hospital NHS Foundation Trust
London
UK
Divulgaciones
JM declares that he has no competing interests.
Hugh Mostafid, MD
Consultant Urologist
North Hampshire Hospital
Basingstoke
UK
利益声明
HM has received honoraria from GE Healthcare and Kyowa Kirin UK.
Thomas Guzzo, MD
Clinical Instructor of Urology
The James Buchanan Brady Urologic Institute
The Johns Hopkins Medical Institutions
Baltimore
MD
Disclosures
TG declares that he has no competing interests.
Amir Kaisary, MD, MA, ChM, FRCS
Consultant Urological Surgeon
Honorary Senior Lecturer
Department of Urology
The Royal Free & University College Medical School
London
UK
Declarações
AK declares that he has no competing interests.
Diagnósticos diferenciais
- Benign prostatic hyperplasia (BPH)
- Hemorrhagic cystitis
- Prostatitis
Mais Diagnósticos diferenciaisDiretrizes
- Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO guideline
- Treatment of non-metastatic muscle-invasive bladder cancer: AUA/ASCO/ASTRO/SUO guideline
Mais DiretrizesPatient information
Bladder cancer
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