When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Mucormycosis

Última revisão: 12 Sep 2025
Última atualização: 11 Apr 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • sinus and facial pain
  • eye pain, blurred vision
  • proptosis
  • cranial nerve palsies
  • dry cough, with or without dyspnea
  • skin nodules
Detalhes completos

Outros fatores diagnósticos

  • fever
  • periorbital cellulitis
  • viscid, dark brown-black nasal discharge
  • focal sensory/motor neurologic deficits and altered mental status
  • necrotic eschar
  • hemoptysis
  • abdominal pain and distension
  • gastrointestinal bleeding
  • peritonitis
Detalhes completos

Fatores de risco

  • diabetes mellitus ± diabetic ketoacidosis
  • hematologic malignancy
  • neutropenia
  • iron overload or use of deferoxamine
  • use of corticosteroids
  • hematopoietic and solid organ transplantation, graft-versus-host disease
  • breakdown of skin and soft tissue
  • malnutrition
  • prematurity
  • liver cirrhosis
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • CBC
  • basic metabolic profile
  • ABG
  • urinalysis
  • serum ketone level
  • CT sinuses and brain
  • MRI sinuses and brain
  • CT chest with contrast
  • nasal endoscopy
  • gastrointestinal endoscopy
Detalhes completos

Investigações a serem consideradas

  • bronchoscopy with bronchoalveolar lavage and/or transbronchial biopsy fungal culture
  • histopathology of biopsy
  • microbiology of biopsy
Detalhes completos

Novos exames

  • polymerase chain reaction (PCR)

Algoritmo de tratamento

AGUDA

suitable for surgery

unsuitable for surgery

CONTÍNUA

treatment failure

Colaboradores

Autores

Rachana M. Palnitkar, MD
Rachana M. Palnitkar

Infectious Diseases

Private Practice

Los Gatos

CA

Declarações

RMP declares that she has no competing interests.

Michael Sands, MD, MPH & TM, FIDSA
Michael Sands

Professor of Medicine

College of Medicine

University of Florida

Jacksonville

FL

Declarações

MS declares that he has no competing interests.

Revisores

Michail Lionakis, MD, ScD

Infectious Diseases Fellow

Laboratory of Molecular Immunology

National Institute of Allergy and Infectious Diseases

NIH

Bethesda

MD

Declarações

ML declares that he has no competing interests.

Rachael Morris-Jones, PhD, FRCP, PCME

Dermatology Consultant and Honorary Senior Lecturer

Kings College Hospital

London

UK

Declarações

RMJ declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Pham D, Howard-Jones AR, Sparks R, et al. Epidemiology, modern diagnostics, and the management of mucorales infections. J Fungi (Basel). 2023 Jun 12;9(6):659.Texto completo  Resumo

Spellberg B, Edwards J Jr, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005 Jul;18(3):556-69.Texto completo  Resumo

Centers for Disease Control and Prevention. Mucormycosis: clinical overview of mucormycosis. Apr 2024 [internet publication].Texto completo

Cornely OA, Alastruey-Izquierdo A, Arenz D, et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 Dec;19(12):e405-21.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Mucormycosis images
  • Diagnósticos diferenciais

    • Aspergillosis
    • Bacterial sinusitis
    • Bacterial periorbital cellulitis
    Mais Diagnósticos diferenciais
  • Diretrizes

    • Global guideline for the diagnosis and management of mucormycosis
    • Global guideline for the diagnosis and management of mucormycosis
    Mais Diretrizes
  • padlock-lockedConectar-se ou assinar para acessar todo o BMJ Best Practice

O uso deste conteúdo está sujeito ao nosso aviso legal