Mucormycosis is predominantly a disease of immunocompromised patients.
Five types are commonly described: rhino-orbito-cerebral (most common), pulmonary, cutaneous, disseminated, and gastrointestinal (rare).
Histopathology of affected tissue is key to obtaining a definitive diagnosis.
Rhinocerebral mucormycosis commonly occurs in patients with diabetes and presents with headache, visual changes, sinusitis, and, later, proptosis.
Pulmonary mucormycosis commonly presents as a cough in patients with underlying malignancy or transplant (bone marrow or solid organ). Late diagnosis may result in dissemination, leading to high mortality.
High level of suspicion and early institution of combined medical therapy with amphotericin-B, surgical treatment, and immune restoration is essential for good outcomes.
Mucormycosis is a group of mould infections caused by fungi in the class previously known as Zygomycetes, now renamed Mucormycetes. The most common manifestations are rhino-orbito-cerebral infections followed by pulmonary, cutaneous, disseminated, and gastrointestinal infections.
History and exam
Rachana M. Palnitkar, MD
RMP declares that she has no competing interests.
Michael Sands, MD, MPH & TM, FIDSA
Professor of Medicine
College of Medicine
University of Florida
MS declares that he has no competing interests.
Michail Lionakis, MD, ScD
Infectious Diseases Fellow
Laboratory of Molecular Immunology
National Institute of Allergy and Infectious Diseases
ML declares that he has no competing interests.
Rachael Morris-Jones, PhD, FRCP, PCME
Dermatology Consultant and Honorary Senior Lecturer
Kings College Hospital
RMJ declares that she has no competing interests.
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