Резюме
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- exposure to fungal spores
- risk factors that impair host defenses
- fever
- headache
- dyspnea
- dry or nonproductive cough
- pleuritic chest pain
- anorexia
- productive cough
Другие диагностические факторы
- abdominal pain
- fatigue
- malaise
- arthralgias
- weight loss
- hepatosplenomegaly
- scattered crackles on chest auscultation
- bronchial breathing on chest auscultation
- distant breath sounds on chest auscultation
- hemoptysis
- meningitis-like symptoms
- skin lesions
- gastrointestinal symptoms
- sepsis-like syndrome
Факторы риска
- exposure to fungus
- emphysema
- HIV infection
- treatment with tumor necrosis factor (TNF)-alpha antagonists
- treatment with corticosteroids
- treatment with immunosuppressants
- neutropenia
- stem cell and solid organ transplant
- graft-versus-host disease
Диагностические исследования
Исследования, которые показаны в первую очередь
- chest x-ray
- culture
- antigen testing
- serology (immunodiffusion precipitin test)
- serology (complement fixation assay)
- serology (enzyme immunoassay)
- CT scan of chest
- CBC
- LFTs
Исследования, проведение которых нужно рассмотреть
- tissue biopsy
Алгоритм лечения
latent asymptomatic disease (nonpregnant)
acute pulmonary disease (nonpregnant)
chronic pulmonary disease (nonpregnant)
disseminated disease (nonpregnant)
mediastinal granuloma (nonpregnant)
mediastinal fibrosis (nonpregnant)
broncholithiasis (nonpregnant)
pericarditis (nonpregnant)
rheumatologic syndrome (nonpregnant)
meningoencephalitis (nonpregnant)
pregnant
Составители
Авторы
Zainab A. Malik, MD, MS, FAAP
Consultant
Pediatrics and Pediatric Infectious Diseases
Mediclinic City Hospital
Dubai
United Arab Emirates
Раскрытие информации
ZAM has received speakers' honoraria from Merck-MSD.
David L. Goldman, MD
Associate Professor
Pediatric Infectious Diseases
The Children's Hospital at Montefiore
New York
NY
Раскрытие информации
DLG declares that he has no competing interests.
Рецензенты
Kassem Hammoud, MD
Associate Professor
Division of Infectious Diseases
University of Kansas Health System
Kansas City
MI
Раскрытие информации
KH declares that he has no competing interests.
Adriana M. Rauseo, MD
Assistant Professor of Medicine
Division of Infectious Diseases
Department of Internal Medicine
Washington University in St Louis
St Louis
MI
Раскрытие информации
AMR declares that she has no competing interests.
Paul Roberts, MD
Assistant Professor
Family Medicine
Mayo Clinic
Jacksonville
FL
Раскрытие информации
PR declares that he has no competing interests.
Janak Koirala, MD
Associate Professor of Medicine
Division of Infectious Diseases
Department of Internal Medicine
Southern Illinois University School of Medicine
Springfield
IL
Раскрытие информации
JK declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007 Oct 1;45(7):807-25.Полный текст Аннотация
Thompson GR 3rd, Le T, Chindamporn A, et al. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis. 2021 Dec;21(12):e364-74.Полный текст Аннотация
National Institutes of Health, Centers for Disease Control and Prevention, HIV Medicine Association, and the Infectious Diseases Society of America. Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: histoplasmosis. Oct 2024 [internet publication].Полный текст
Hage CA, Carmona EM, Epelbaum O, et al. Microbiological laboratory testing in the diagnosis of fungal infections in pulmonary and critical care practice. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2019 Sep 1;200(5):535-50.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Community-acquired pneumonia
- Pneumocystis jirovecii pneumonia (PCP)
- Pulmonary tuberculosis
Больше ОтличияРекомендации
- Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: histoplasmosis
- Clinical testing guidance for coccidioidomycosis, histoplasmosis, and blastomycosis in patients with community-acquired pneumonia
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