Listeriosis
小结
定义
病史和体格检查
关键诊断因素
- fever
- diarrhea and abdominal pain
- flu-like symptoms in pregnancy
其他诊断因素
- headache
- altered mental status
- meningismus
- cranial nerve deficits
- cerebellar signs
- focal neurologic signs
- seizures
- hypotension
- generalized malaise
- intrapartum fever
- poor feeding (neonates)
- bleeding diathesis with hemorrhage
- cardiac murmur
危险因素
- exposure to contaminated food
- age >45-50 years
- pregnancy
- neonates
- immunocompromised states
- impaired stomach acidification
诊断性检查
首要检查
- CBC
- urine pregnancy test
- blood cultures
- brain MRI
- brain CT
- cerebrospinal fluid (CSF) analysis
需考虑的检查
- prothrombin time (PT) and PTT
- D-dimer
- placenta and amniotic fluid culture
- cervical swab culture
- meconium Gram stain and culture
- Listeria serology
- food analysis
- stool culture
- polymerase chain reaction of blood
- other stool analyses
- electroencephalogram
- echocardiography
治疗流程
gastroenteritis
systemic infection (excluding meningitis/meningoencephalitis)
meningitis/meningoencephalitis
撰稿人
作者
Petros M. Karsaliakos, MD, FRCP, MSc
Honorary Clinical Senior Lecturer
Glasgow University
Consultant in General Medicine
Queen Elizabeth University Hospital
NHS GGC
Scotland
利益声明
PMK declares that he has no competing interests.
Eleftherios Mylonakis, MD, PhD, FIDSA, FAAM
Charles C.J. Carpenter Professor of Infectious Disease
Chair, Department of Medicine
Charles and Anne Duncan Presidential Distinguished Chair
Professor of Medicine, Weill Cornell Medical College & Houston Methodist Academic Institute
Adjunct Professor of Medicine, Warren Alpert Medical School of Brown University
Adjunct Clinical Professor, Texas A&M College of Medicine
Houston Methodist Hospital
Houston, TX
利益声明
EM is an author of several references cited in this topic.
同行评议者
Josiah D. Rich, MD, MPH
Professor of Medicine and Community Health
Brown University
Providence
RI
利益声明
JDR declares that he has no competing interests.
Alistair Leonord, MBChB, BSc, MRCPath, MD, DTM&H
Professor
Infection and Immunity
Consultant Microbiologist
Bacteriology Dept
Southern General Hospital
Glasgow
UK
利益声明
AL declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Mylonakis E, Hofmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore). 1998 Sep;77(5):313-36. 摘要
Quereda JJ, Morón-García A, Palacios-Gorba C, et al. Pathogenicity and virulence of listeria monocytogenes: a trip from environmental to medical microbiology. Virulence. 2021 Dec;12(1):2509-45.全文 摘要
Committee on Obstetric Practice, American College of Obstetricians and Gynecologists. Committee opinion no. 614: management of pregnant women with presumptive exposure to listeria monocytogenes. Obstet Gynecol. 2014 Dec;124(6):1241-4. 摘要
Centers for Disease Control and Prevention. Listeria infection (listeriosis): clinical overview of listeriosis Aug 2024 [internet publication].全文
Osek J, Lachtara B, Wieczorek K. Listeria monocytogenes - how this pathogen survives in food-production environments? Front Microbiol. 2022;13:866462.全文 摘要
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
鉴别诊断
- Other bacterial meningitides
- Other brain abscesses
- Viral gastroenteritis
更多 鉴别诊断指南
- Listeria (Listeriosis)
- Listeria infection (Listeriosis)
更多 指南
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