Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- fever
- constitutional symptoms
- conjunctival injection
- relative bradycardia (Faget's sign)
- biphasic illness
- jaundice
- haemorrhagic diathesis
- signs of renal failure
- signs of hepatic failure
Risk factors
- residence in, or recent travel to, endemic area
- lack of immunisation
- mosquito bite
- travel during rainy and early dry seasons
Diagnostic investigations
1st investigations to order
- FBC
- LFTs
- coagulation screen
- reverse transcription polymerase chain reaction (RT-PCR)
- serology
Treatment algorithm
Contributors
Authors

Heyward Gibbes Distinguished Professor of Internal Medicine
Chair
Department of Internal Medicine
University of South Carolina
Columbia
SC
Disclosures
HA declares that he has no competing interests.
Dr Albrecht would like to gratefully acknowledge Dr Philip A. Yeon, a previous contributor to this monograph. PAY declares that he has no competing interests.
Peer reviewers
Assistant Professor
Emory University
TravelWell Clinic
Emory University Hospital Midtown
Atlanta
GA
Disclosures
CFP declares that he has no competing interests.
Clinical Assistant
Tropical Diseases Unit
Division of Infectious Diseases
Department of Medicine
Toronto General Hospital
University Health Network
Toronto
Canada
Disclosures
AKB declares that she has no competing interests.
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