Summary
定义
病史和体格检查
关键诊断因素
- history of residence in, or recent travel to, endemic area
- lack of yellow fever immunization
- history of mosquito bite
- fever
- constitutional symptoms
- conjunctival injection
- relative bradycardia (Faget sign)
- biphasic illness
- hemorrhagic diathesis
- signs of renal failure
- signs of hepatic failure
- jaundice
其他诊断因素
- hypotension
- abdominal pain, vomiting, and lethargy
危险因素
- residence in, or recent travel to, endemic area
- lack of immunization
- mosquito bite
- travel during rainy and early dry seasons
Diagnostic tests
1st tests to order
- CBC
- liver function tests
- coagulation screen
- reverse transcription polymerase chain reaction (RT-PCR)
- serology
Tests to consider
- ECG
- histopathology
Emerging tests
- virus isolation
- isothermal nucleic acid amplification assays
Treatment algorithm
all patients
Contributors
Authors
William A. Messer, MD, PhD
Associate Professor of Medicine
Department of Molecular Microbiology and Immunology
Division of Infectious Diseases
Oregon Health & Science University
Portland
OR
Disclosures
WAM declares that he has no competing interests.
Acknowledgements
Dr William A. Messer would like to gratefully acknowledge Dr Philip A. Yeon and Dr Helmut Albrecht, previous contributors to this topic.
Disclosures
PAY and HA declares that he has no competing interests.
Peer reviewers
Carlos Franco-Paredes, MD, MPH
Assistant Professor
Emory University
TravelWell Clinic
Emory University Hospital Midtown
Atlanta
GA
Declarações
CFP declares that he has no competing interests.
Andrea K. Boggild, MSc, MD, DTMH, FRCPC
Clinical Assistant
Tropical Diseases Unit
Division of Infectious Diseases
Department of Medicine
Toronto General Hospital
University Health Network
Toronto
Canada
Declarações
AKB declares that she has no competing interests.
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Referências
Principais artigos
Centers for Disease Control and Prevention. CDC Yellow Book 2026: health information for international travel. Travel-associated infectious and diseases - yellow fever. Apr 2025 [internet publication].Texto completo
Centers for Disease Control and Prevention. Yellow fever virus: clinical features and diagnosis of yellow fever. Nov 2025 [internet publication].Texto completo
World Health Organization. WHO guidelines for clinical management of arboviral diseases. 2025 [internet publication].Texto completo
Staples JE, Bocchini JA Jr, Rubin L; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine booster doses: recommendations of the Advisory Committee on Immunization Practices, 2015. MMWR Morb Mortal Wkly Rep. 2015;64:647-650.Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Diagnósticos diferenciais
- Dengue fever
- Malaria
- Zika virus infection
Mais Diagnósticos diferenciaisDiretrizes
- Yellow fever outbreak toolbox
- Yellow fever vaccine information for healthcare providers
Mais Diretrizes
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