Summary
Differentials
Common
- Sepsis
- Typhoid
- Brucellosis
- HIV
- Hepatitis
- Influenza
- Infectious mononucleosis
- Respiratory syncytial virus
- Erythema infectiosum
- Rickettsia
- Drug-induced
- Cytotoxic chemotherapy
- Radiotherapy
- Immune neutropenia
- Acute myelogenous leukaemia
- Acute lymphocytic leukaemia
- Myelodysplastic syndrome
- Chronic lymphocytic leukaemia (CLL)
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Infiltration by secondary malignancy
- Aplastic anaemia
- Vitamin B12/folate deficiency
- Alcohol misuse
Uncommon
- Cytomegalovirus
- Rubella
- Measles
- Chicken pox
- Human granulocytic ehrlichiosis
- Malaria
- Leishmaniasis
- Transfusion reaction
- Copper deficiency
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Sjogren's syndrome
- Felty's syndrome
- Increased neutrophil margination
- Laboratory artifact
- Bone marrow failure syndromes
- Isolated neutropenia syndromes
- Immunodeficiency syndromes
- Inborn errors of metabolism
Contributors
Authors
Edward Copelan, MD, FACP
Professor and Chairman
Department of Hematologic Oncology and Blood Disorders
Levine Cancer Institute
Carolinas HealthCare System
Charlotte
NC
Disclosures
EC is a member of the Amgen Executive Advisory Board.
Belinda Avalos, MD
Professor and Vice-Chair
Department of Hematologic Oncology and Blood Disorders
Levine Cancer Institute
Carolinas HealthCare System
Charlotte
NC
Disclosures
BA declares that she has no competing interests.
Reed Friend, MD
Assistant Professor
Hematologic Oncology and Blood Disorders
Levine Cancer Institute
Carolinas HealthCare System
Charlotte
NC
Disclosures
RF has been reimbursed by Amgen and Takeda Oncology for serving on the speakers' bureau for carfilzomib, xgeva, and ixazomib.
Acknowledgements
Dr Edward Copelan, Dr Belinda Avalos, and Dr Reed Friend would like to gratefully acknowledge Dr Lisa Sproat, the previous contributor to this topic.
Disclosures
LS declares that she has no competing interests.
Peer reviewers
Sally E. Kinsey, MD, FRCP, FRCPath, FRCPCH
Professor of Paediatric Haematology
University of Leeds and Leeds Teaching Hospitals NHS Trust
St. James's University Hospital
Leeds
UK
Disclosures
SEK is a medical advisory board member of the Severe Chronic Neutropenia International Registry (not remunerated) and is an author of references cited in the topic including data from the registry. SEK has been in receipt of educational grants from Chugai Pharma.
Laurence A. Boxer, MD
Professor
Pediatric Hematology/Oncology
Associate Chair
Department of Pediatrics and Communicable Diseases
Henry and Mala Dorfman Family Professorship
Pediatric Hematology/Oncology
Ann Arbor
MI
Disclosures
LAB is an author of references cited in this topic. LAB declares that he has no competing interests.
Cornelia Zeidler, MD
SCNIR
DCC Europe
Medizinische Hochschule Hannover
Kinderklinik
Hannover
Germany
Disclosures
Not disclosed.
Guidelines
- Outpatient management of fever and neutropenia in adults treated for malignancy
- Neutropenic sepsis: prevention and management in people with cancer
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