Assessment of neutropenia

Last reviewed: 28 Feb 2023
Last updated: 02 Sep 2022

Summary

Differentials

Common

  • Sepsis
  • Typhoid
  • Brucellosis
  • HIV
  • Hepatitis
  • Influenza
  • Infectious mononucleosis
  • Respiratory syncytial virus
  • Erythema infectiosum
  • Rickettsia
  • Drug-induced
  • Cytotoxic chemotherapy
  • Radiotherapy
  • Immune neutropenia
  • Acute myelogenous leukaemia
  • Acute lymphocytic leukaemia
  • Myelodysplastic syndrome
  • Chronic lymphocytic leukaemia (CLL)
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma
  • Infiltration by secondary malignancy
  • Aplastic anaemia
  • Vitamin B12/folate deficiency
  • Alcohol misuse
Full details

Uncommon

  • Cytomegalovirus
  • Rubella
  • Measles
  • Chicken pox
  • Human granulocytic ehrlichiosis
  • Malaria
  • Leishmaniasis
  • Transfusion reaction
  • Copper deficiency
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Sjogren's syndrome
  • Felty's syndrome
  • Increased neutrophil margination
  • Laboratory artifact
  • Bone marrow failure syndromes
  • Isolated neutropenia syndromes
  • Immunodeficiency syndromes
  • Inborn errors of metabolism
Full details

Contributors

Authors

Edward Copelan, MD, FACP

Professor and Chairman

Department of Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

EC is a member of the Amgen Executive Advisory Board.

Belinda Avalos, MD

Professor and Vice-Chair

Department of Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

BA declares that she has no competing interests.

Reed Friend, MD

Assistant Professor

Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

RF has been reimbursed by Amgen and Takeda Oncology for serving on the speakers' bureau for carfilzomib, xgeva, and ixazomib.

Acknowledgements

Dr Edward Copelan, Dr Belinda Avalos, and Dr Reed Friend would like to gratefully acknowledge Dr Lisa Sproat, the previous contributor to this topic.

Disclosures

LS declares that she has no competing interests.

Peer reviewers

Sally E. Kinsey, MD, FRCP, FRCPath, FRCPCH

Professor of Paediatric Haematology

University of Leeds and Leeds Teaching Hospitals NHS Trust

St. James's University Hospital

Leeds

UK

Disclosures

SEK is a medical advisory board member of the Severe Chronic Neutropenia International Registry (not remunerated) and is an author of references cited in the topic including data from the registry. SEK has been in receipt of educational grants from Chugai Pharma.

Laurence A. Boxer, MD

Professor

Pediatric Hematology/Oncology

Associate Chair

Department of Pediatrics and Communicable Diseases

Henry and Mala Dorfman Family Professorship

Pediatric Hematology/Oncology

Ann Arbor

MI

Disclosures

LAB is an author of references cited in this topic. LAB declares that he has no competing interests.

Cornelia Zeidler, MD

SCNIR

DCC Europe

Medizinische Hochschule Hannover

Kinderklinik

Hannover

Germany

Disclosures

Not disclosed.

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