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VIPoma

Última revisão: 13 Feb 2025
Última atualização: 19 Jul 2024

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • profuse watery diarrhea
Detalhes completos

Outros fatores diagnósticos

  • age around 50 years
  • headache
  • weight loss
  • poor skin turgor
  • dry mucus membranes
  • muscle weakness
  • muscle cramps
  • flushing
  • hepatomegaly
  • history of multiple endocrine neoplasia type 1 (MEN1)
Detalhes completos

Fatores de risco

  • multiple endocrine neoplasia type 1 (MEN1)
  • age around 50 years
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • serum potassium
  • serum bicarbonate
  • serum calcium
  • serum glucose
  • vasoactive intestinal peptide (VIP) radioimmunoassay
  • liver function tests
Detalhes completos

Investigações a serem consideradas

  • arterial blood gas analysis
  • gastric pH monitoring
  • chromogranin A
  • pancreatic polypeptide
  • contrast-enhanced CT scan of abdomen
  • contrast-enhanced MRI of abdomen
  • somatostatin receptor PET/CT
  • somatostatin receptor scintigraphy
  • endoscopic ultrasound
  • abdominal ultrasound
  • operative exploration
  • intraoperative ultrasound
Detalhes completos

Algoritmo de tratamento

AGUDA

initial presentation of symptomatic patient

CONTÍNUA

localized disease

metastatic disease: surgical candidate

metastatic disease: nonsurgical candidate

refractory disease

Colaboradores

Autores

Harish Lavu, MD, FACS
Harish Lavu

Professor of Surgery

Sidney Kimmel Medical College

Thomas Jefferson University

Philadelphia

PA

Declarações

HL declares that he has no competing interests.

Charles J. Yeo, MD, FACS
Charles J. Yeo

The Samuel D. Gross Professor and Chair

Department of Surgery

Sidney Kimmel Medical College

Thomas Jefferson University

Philadelphia

PA

Declarações

CJY declares that he has no competing interests.

Revisores

Jaime Ruiz-Tovar, MD

Fellow of the Spanish Association of Surgeons (AEC)

Department of Surgery

University Hospital Ramon y Cajal

Madrid

Spain

Declarações

JRT declares that he has no competing interests.

Christopher Wolfgang, MD, PhD, FACS

Assistant Professor of Surgery and Oncology

Cameron Division of Surgical Oncology

The Sol Goldman Pancreatic Cancer Research Center

Johns Hopkins University

Baltimore

MD

Declarações

CW declares that he has no competing interests.

  • VIPoma images
  • Diagnósticos diferenciais

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    • Osmotic diarrhea
    • Ileal bile acid malabsorption
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  • Diretrizes

    • NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
    • NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
    Mais Diretrizes
  • Folhetos informativos para os pacientes

    Diarrhea in adults

    Diarrhea in children

    Mais Folhetos informativos para os pacientes
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