Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- profuse watery diarrhea
Outros fatores diagnósticos
- age around 50 years
- headache
- weight loss
- poor skin turgor
- dry mucus membranes
- muscle weakness
- muscle cramps
- flushing
- hepatomegaly
- history of multiple endocrine neoplasia type 1 (MEN1)
Fatores de risco
- multiple endocrine neoplasia type 1 (MEN1)
- age around 50 years
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- serum potassium
- serum bicarbonate
- serum calcium
- serum glucose
- vasoactive intestinal peptide (VIP) radioimmunoassay
- liver function tests
Investigações a serem consideradas
- arterial blood gas analysis
- gastric pH monitoring
- chromogranin A
- pancreatic polypeptide
- contrast-enhanced CT scan of abdomen
- contrast-enhanced MRI of abdomen
- somatostatin receptor PET/CT
- somatostatin receptor scintigraphy
- endoscopic ultrasound
- abdominal ultrasound
- operative exploration
- intraoperative ultrasound
Algoritmo de tratamento
initial presentation of symptomatic patient
localized disease
metastatic disease: surgical candidate
metastatic disease: nonsurgical candidate
refractory disease
Colaboradores
Autores
Harish Lavu, MD, FACS

Professor of Surgery
Sidney Kimmel Medical College
Thomas Jefferson University
Philadelphia
PA
Declarações
HL declares that he has no competing interests.
Charles J. Yeo, MD, FACS

The Samuel D. Gross Professor and Chair
Department of Surgery
Sidney Kimmel Medical College
Thomas Jefferson University
Philadelphia
PA
Declarações
CJY declares that he has no competing interests.
Revisores
Jaime Ruiz-Tovar, MD
Fellow of the Spanish Association of Surgeons (AEC)
Department of Surgery
University Hospital Ramon y Cajal
Madrid
Spain
Declarações
JRT declares that he has no competing interests.
Christopher Wolfgang, MD, PhD, FACS
Assistant Professor of Surgery and Oncology
Cameron Division of Surgical Oncology
The Sol Goldman Pancreatic Cancer Research Center
Johns Hopkins University
Baltimore
MD
Declarações
CW declares that he has no competing interests.
Diagnósticos diferenciais
- Infectious gastroenteritis
- Osmotic diarrhea
- Ileal bile acid malabsorption
Mais Diagnósticos diferenciaisDiretrizes
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
Mais DiretrizesFolhetos informativos para os pacientes
Diarrhea in adults
Diarrhea in children
Mais Folhetos informativos para os pacientesConectar-se ou assinar para acessar todo o BMJ Best Practice
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