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VIPoma

Última revisão: 24 Jul 2025
Última atualização: 26 Mar 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • profuse watery diarrhea
Detalhes completos

Outros fatores diagnósticos

  • age around 50 years
  • headache
  • weight loss
  • poor skin turgor
  • dry mucus membranes
  • muscle weakness
  • muscle cramps
  • gastrointestinal symptoms
  • hyperglycemia symptoms
  • flushing
  • hepatomegaly
  • history of multiple endocrine neoplasia type 1 (MEN1)
Detalhes completos

Fatores de risco

  • multiple endocrine neoplasia type 1 (MEN1)
  • age around 50 years
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • serum potassium
  • serum bicarbonate
  • serum calcium
  • serum glucose
  • vasoactive intestinal peptide (VIP) radioimmunoassay
  • liver function tests
Detalhes completos

Investigações a serem consideradas

  • arterial blood gas analysis
  • gastric pH monitoring
  • chromogranin A
  • pancreatic polypeptide
  • contrast-enhanced CT scan of abdomen
  • contrast-enhanced MRI of abdomen
  • somatostatin receptor PET-CT/MRI
  • somatostatin receptor scintigraphy
  • endoscopic ultrasound
  • operative exploration
  • intraoperative ultrasound
  • biopsy
Detalhes completos

Algoritmo de tratamento

AGUDA

initial presentation of symptomatic patient

CONTÍNUA

localized disease

metastatic disease: surgical candidate

metastatic disease: nonsurgical candidate

refractory disease

Colaboradores

Autores

Harish Lavu, MD, FACS
Harish Lavu

Professor of Surgery

Sidney Kimmel Medical College

Thomas Jefferson University

Philadelphia

PA

Declarações

HL declares that he has no competing interests.

Charles J. Yeo, MD, FACS
Charles J. Yeo

The Samuel D. Gross Professor and Chair

Department of Surgery

Sidney Kimmel Medical College

Thomas Jefferson University

Philadelphia

PA

Declarações

CJY declares that he has no competing interests.

Revisores

Alexandria Phan, MD

Professor of Medicine

Froedtert Hospital and the Medical College of Wisconsin

Milwaukee

WI

Declarações

AP declares that she has no competing interests.

Jonathan Strosberg, MD

Professor

Moffitt Cancer Center

Tampa

FL

Declarações

JS has consulted for Novartis and serves on the Speakers’ Bureau for Ipsen.

Jaime Ruiz-Tovar, MD

Fellow of the Spanish Association of Surgeons (AEC)

Department of Surgery

University Hospital Ramon y Cajal

Madrid

Spain

Declarações

JRT declares that he has no competing interests.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors [internet publication].Texto completo

Hofland J, Falconi M, Christ E, et al. European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes. J Neuroendocrinol. 2023 Aug;35(8):e13318.Texto completo  Resumo

Pavel M, Öberg K, Falconi M, et al. Gastroenteropancreatic neuroendocrine neoplasms: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020 Jul;31(7):844-60.Texto completo

Del Rivero J, Perez K, Kennedy EB, et al. Systemic therapy for tumor control in metastatic well-differentiated gastroenteropancreatic neuroendocrine tumors: ASCO guideline. J Clin Oncol. 2023 Nov 10;41(32):5049-67.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • VIPoma images
  • Diagnósticos diferenciais

    • Infectious gastroenteritis
    • Osmotic diarrhea
    • Ileal bile acid malabsorption
    Mais Diagnósticos diferenciais
  • Diretrizes

    • NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
    • NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
    Mais Diretrizes
  • Folhetos informativos para os pacientes

    Diarrhea in children

    Mais Folhetos informativos para os pacientes
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