Lymphadenopathy is defined as lymph nodes that are abnormal in size, consistency or number. The extent of lymphadenopathy is defined as localised, regional or generalised. Lymphadenopathy is commonly encountered by physicians in clinical practice and requires a comprehensive evaluation. When initiating a work-up, the physician should pay close attention to the size, location, consistency and number of enlarged lymph nodes, as well as to the patient's age and any associated symptoms. Lymphadenopathy may be due to malignancy, hypersensitivity, infection, collagen vascular disease, atypical lymphoproliferative disorders, granulomatous diseases and other miscellaneous causes.   
Section of Hematology and Medical Oncology
Professor of Medicine, Thrombosis Research, and Pharmacology
Temple University School of Medicine
Department of Medicine
MEB declares that he has no competing interests.
Dr Michael E. Bromberg would like to gratefully acknowledge Dr Efrat Dotan, a previous contributor to this monograph. ED declares that she has no competing interests.
PS declares that she has no competing interests.
Section of Hematology and Oncology
Department of Internal Medicine
Wake Forest University Baptist Medical Center
RC declares that she has no competing interests.
Professor of Medicine
Hematology Malignancies and Blood & Marrow Transplant Program
University of Colorado at Denver and Health Sciences Center
HM declares that he has no competing interests.
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