Last reviewed: 26 Jan 2021
Last updated: 26 Nov 2020
Summary
Definition
History and exam
Key diagnostic factors
- history of asthma
- history of cystic fibrosis (CF)
- teenagers and young adults with CF
- history of atopy
- cough
- mucus plugs
- wheezing
Other diagnostic factors
- fever
- pleuritic chest pain
- haemoptysis
- finger clubbing
- cyanosis
- weight loss
Risk factors
- asthma
- cystic fibrosis
- atopy
- HLA-DR2- and HLA-DR5-positive
- IL-10 promoter polymorphisms
- surfactant protein polymorphisms
- CFTR gene
Diagnostic investigations
1st investigations to order
- skin test for Aspergillus fumigatus sensitivity
- serum total IgE
- FBC with peripheral blood eosinophil count
- chest x-ray
- CT chest
- Aspergillus-specific IgE
Investigations to consider
- Aspergillus-specific IgG
- serum precipitating antibodies to Aspergillus fumigatus
- sputum culture and microscopy
- HLA antigens
Treatment algorithm
Contributors
Authors
Staff Physician
Department of Pulmonary, Allergy and Critical Care
Cleveland Clinic
Cleveland
OH
Disclosures
CR is on the Advisory Board for CSL Behring and the Speakers Bureau for BioCryst.
Peer reviewers
Professor
Department of Pediatrics
University of Bern
Bern
Switzerland
Disclosures
MS declares that he has no competing interests.
Professor of Pediatrics
Allergy-Immunology Division
Medical College of Wisconsin
Milwaukee
WI
Disclosures
JF is an author of a number of references cited in this topic.
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