Evaluation of maculopapular rash

Last reviewed: 7 Apr 2025
Last updated: 15 Nov 2024

Summary

Differentials

Common

  • Allergy to food or drug
  • Insect bites or stings
  • Adverse drug reaction (e.g., to antibiotic, anticonvulsant, or allopurinol)
  • Chemotherapy
  • Enterovirus and echovirus infection
  • Fifth disease (erythema infectiosum)
  • Roseola infantum (sixth disease)
  • Epstein Barr virus (EBV) infection (infectious mononucleosis)
  • Cytomegalovirus (CMV) infection
Full details

Uncommon

  • Iodinated contrast media nonimmediate adverse reaction
  • Toxic epidermal necrolysis/Stevens-Johnson syndrome
  • Drug reaction with eosinophilia and systemic symptoms
  • Erythema multiforme
  • HIV-seroconversion exanthema (also known as acute retroviral syndrome)
  • Mpox
  • Sepsis
  • Acute hepatitis B virus infection
  • Acute hepatitis C virus infection
  • Rubella (German measles)
  • Rubeola (measles)
  • Meningococcemia
  • Scarlet fever
  • Staphylococcal scalded skin syndrome
  • Toxic shock syndrome (Staphylococcus exotoxin)
  • Rocky Mountain spotted fever or Mediterranean spotted fever
  • Acute graft-versus-host disease
  • Kawasaki disease (mucocutaneous lymph node syndrome)
  • Juvenile-onset or adult-onset Still disease
  • Syphilis (secondary)
  • Ebola virus infection
  • Zika virus infection
  • Chikungunya virus infection
  • Dengue fever
Full details

Contributors

Authors

Adelaide A. Hebert, MD

Professor & Director of Pediatric Dermatology

Department of Dermatology and Pediatrics

UTHealth McGovern Medical School Houston

Houston

TX

Disclosures

AAH has received research grants paid to UTHealth McGovern Medical School Houston from Pfizer, GlaxoSmithKline (GSK), Novan, Dermavant, Arcutis, and Verrica; has received honoraria from Pfizer, Verrica, and Novan; and is on data safety monitoring boards for GSK, Ortho Dermatologics, and Regeneron-Sanofi.

Yamila Goenaga, MD

Dermatology Resident

Department of Dermatology

University of Texas Health Sciences Center in Houston

Houston

TX

Disclosures

YG declares that she has no competing interests.

Alexander J. Jafari, MD, MPH

Clinical Research Fellow

Department of Dermatology

UTHealth McGovern Medical School Houston

Houston

TX

Disclosures

AJJ declares that he has no competing interests.

Acknowledgements

Dr Adelaide A. Hebert, Dr Yamila Goenaga, and Dr. Alexander Jafari would like to gratefully acknowledge Dr Quoc-Bao Nguyen, Dr Mary DarConte, Dr Mark Naftanel, and Dr Hobart W. Walling, previous contributors to this topic.

Disclosures

QN, MD, MN, and HWW declare that they have no competing interests.

Peer reviewers

Brian Swick, MD

Clinical Assistant Professor

University of Iowa College of Medicine

Iowa City

IA

Disclosures

BS declares that he has no competing interests.

Kimberly Schulz, MD

Dermatologist

Town Square Dermatology

Coralville

IA

Disclosures

KS declares that she has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Resuscitation Council UK. Emergency treatment of anaphylactic reactions: guidelines for healthcare providers. May 2021 [internet publication].Full text

Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology, et al. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010 Oct;105(4):259-73. Abstract

McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017 Apr 25;135(17):e927-99.Full text  Abstract

Khan DA, Banerji A, Blumenthal KG, et al. Drug allergy: a 2022 practice parameter update. J Allergy Clin Immunol. 2022 Dec;150(6):1333-93.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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