Roseola

Last reviewed: 19 Apr 2022
Last updated: 23 Apr 2020

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • high fever
  • exanthem
More key diagnostic factors

Other diagnostic factors

  • diarrhoea
  • abdominal pain
  • Nagayama's spots
  • tympanic membrane inflammation
  • upper respiratory symptoms
  • seizures
  • peri-orbital oedema
  • bulging anterior fontanelle
  • cervical, occipital, or post-auricular lymphadenopathy
Other diagnostic factors

Risk factors

  • age under 2 years
  • immunosuppression
More risk factors

Diagnostic investigations

1st investigations to order

  • no initial test
More 1st investigations to order

Investigations to consider

  • viral culture
  • antibody detection
More investigations to consider

Emerging tests

  • polymerase chain reaction
  • immunohistochemistry

Treatment algorithm

ACUTE

roseola

Contributors

Authors

Edward C. Kim, MD

Assistant Professor of Pediatric Infectious Disease and Immunology

University of Connecticut Medical Center and Connecticut Children’s Medical Center

Hartford

CT

Disclosures

ECK declares that he has no competing interests.

Henry M. Feder, Jr., MD

Professor of Pediatrics and Family Medicine

University of Connecticut Medical Center and Connecticut Children’s Medical Center

Farmington

CT

Disclosures

HMF declares that he has no competing interests.

Acknowledgements

Dr Edward C. Kim and Dr Henry M. Feder would like to gratefully acknowledge Dr Nicholas Bennett, Dr James Azim, Dr Margie C. Andreae, Dr Jon Dyer, and Dr Jennifer Holman, the previous contributors to this topic. NB, JA, MCA, JD, and JH declare that they have no competing interests.

Peer reviewers

Helen Goodyear, MBChB, MRCP, FRCPCH, MD, MMed

Consultant Paediatrician

Heartlands Hospital

Birmingham

UK

Disclosures

HG declares that she has no competing interests.

Mary T. Caserta, MD

Associate Professor of Pediatrics

Department of Pediatrics

Division of Infectious Diseases

University of Rochester Medical Center

Rochester

NY

Disclosures

MTC declares that she has no competing interests.

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