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Breast cancer in situ

Last reviewed: 30 Apr 2025
Last updated: 30 Apr 2025

Summary

Definition

História e exame físico

Principais fatores diagnósticos

  • family history of breast cancer
Detalhes completos

Outros fatores diagnósticos

  • nipple discharge
  • breast lump
  • eczema-like rash on nipple
  • ulceration
Detalhes completos

Fatores de risco

  • family history of breast cancer
  • benign breast disease on prior biopsy
  • hereditary breast ovarian cancer syndrome
  • Li-Fraumeni syndrome
  • Cowden syndrome
  • hereditary diffuse gastric cancer (HDGC)
  • Peutz-Jeghers syndrome
  • Klinefelter syndrome
  • older age at menopause
  • older age at first full-term pregnancy
  • nulliparity
  • low physical activity
  • high vitamin A intake
  • ataxia telangiectasia
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • mammography
Detalhes completos

Tests to avoid

  • PET, CT, or radionuclide bone scans
Detalhes completos

Investigações a serem consideradas

  • core needle biopsy
  • excisional biopsy
  • sentinel lymph node biopsy (SLNB)
  • breast magnetic resonance imaging (MRI)
  • breast ultrasound
  • hormone receptor testing
  • genetic evaluation
Detalhes completos

Algoritmo de tratamento

AGUDA

women with low-risk ductal carcinoma in situ

women with high-risk DCIS; all men with DCIS

lobular carcinoma in situ

CONTÍNUA

local recurrence of DCIS

Colaboradores

Autores

Edward R. Sauter, MD, PhD
Edward R. Sauter

Medical Officer

Breast and Gynecologic Cancer Working Group

Division of Cancer Prevention

National Cancer Institute

Bethesda

MD

Declarações

ERS is an author of a reference cited in this topic.

Agradecimentos

Dr Edward R. Sauter would like to gratefully acknowledge Dr Rachel L. Ruhlen, a previous contributor to this topic.

Declarações

RLR declares that she has no competing interests.

Revisores

Carla Boetes, MD, PhD

Radiologist

Radboud University Nijmegen Medical Centre

Nijmegen

The Netherlands

Declarações

CB is an author of a number of references cited in this topic.

Alessandra Balduzzi, MD

Assistant in the Division of Medical Oncology

European Institute of Oncology

Milan

Italy

Declarações

AB declares that she has no competing interests.

Kala Visvanathan, MBBS, FRACP, MHS

Associate Professor in Epidemiology and Medical Oncology

Johns Hopkins School of Medicine and Bloomberg School of Public Health

Baltimore

MD

Declarações

KV is an author of a number of references cited in this topic.

Glyn T. Neades, MB ChB, FRCS(Glas), FRCS(Ed), ChM

Consultant Surgeon and Honorary Senior Lecturer

Edinburgh Breast Unit

Western General Hospital

Edinburgh

UK

Declarações

GTN is a principal investigator for the IBIS-II trial, and is an author of a guideline cited in this topic.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer risk reduction [internet publication].Texto completo

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer [internet publication].Texto completo

Loibl S, André F, Bachelot T, et al. Early breast cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2024 Feb;35(2):159-82.Texto completo

Morrow M, Van Zee KJ, Solin LJ, et al. Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ. J Clin Oncol. 2016 Nov 20;34(33):4040-6. [Reaffirmed 2019.]Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Breast cancer in situ images
  • Diagnósticos diferenciais

    • Invasive breast cancer
    • Atypical hyperplasia
    • Fibroadenoma
    Mais Diagnósticos diferenciais
  • Diretrizes

    • NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis
    • NCCN clinical practice guidelines in oncology: breast cancer risk reduction​
    Mais Diretrizes
  • Folhetos informativos para os pacientes

    Breast cancer: DCIS (very early breast cancer) in women

    Breast cancer, locally advanced: what is it?

    Mais Folhetos informativos para os pacientes
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