Summary
Definition
História e exame físico
Principais fatores diagnósticos
- family history of breast cancer
Outros fatores diagnósticos
- nipple discharge
- breast lump
- eczema-like rash on nipple
- ulceration
Fatores de risco
- family history of breast cancer
- benign breast disease on prior biopsy
- hereditary breast ovarian cancer syndrome
- Li-Fraumeni syndrome
- Cowden syndrome
- hereditary diffuse gastric cancer (HDGC)
- Peutz-Jeghers syndrome
- Klinefelter syndrome
- older age at menopause
- older age at first full-term pregnancy
- nulliparity
- low physical activity
- high vitamin A intake
- ataxia telangiectasia
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- mammography
Tests to avoid
- PET, CT, or radionuclide bone scans
Investigações a serem consideradas
- core needle biopsy
- excisional biopsy
- sentinel lymph node biopsy (SLNB)
- breast magnetic resonance imaging (MRI)
- breast ultrasound
- hormone receptor testing
- genetic evaluation
Algoritmo de tratamento
women with low-risk ductal carcinoma in situ
women with high-risk DCIS; all men with DCIS
lobular carcinoma in situ
local recurrence of DCIS
Colaboradores
Autores
Edward R. Sauter, MD, PhD

Medical Officer
Breast and Gynecologic Cancer Working Group
Division of Cancer Prevention
National Cancer Institute
Bethesda
MD
Declarações
ERS is an author of a reference cited in this topic.
Agradecimentos
Dr Edward R. Sauter would like to gratefully acknowledge Dr Rachel L. Ruhlen, a previous contributor to this topic.
Declarações
RLR declares that she has no competing interests.
Revisores
Carla Boetes, MD, PhD
Radiologist
Radboud University Nijmegen Medical Centre
Nijmegen
The Netherlands
Declarações
CB is an author of a number of references cited in this topic.
Alessandra Balduzzi, MD
Assistant in the Division of Medical Oncology
European Institute of Oncology
Milan
Italy
Declarações
AB declares that she has no competing interests.
Kala Visvanathan, MBBS, FRACP, MHS
Associate Professor in Epidemiology and Medical Oncology
Johns Hopkins School of Medicine and Bloomberg School of Public Health
Baltimore
MD
Declarações
KV is an author of a number of references cited in this topic.
Glyn T. Neades, MB ChB, FRCS(Glas), FRCS(Ed), ChM
Consultant Surgeon and Honorary Senior Lecturer
Edinburgh Breast Unit
Western General Hospital
Edinburgh
UK
Declarações
GTN is a principal investigator for the IBIS-II trial, and is an author of a guideline cited in this topic.
Referências
Principais artigos
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer risk reduction [internet publication].Texto completo
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: breast cancer [internet publication].Texto completo
Loibl S, André F, Bachelot T, et al. Early breast cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2024 Feb;35(2):159-82.Texto completo
Morrow M, Van Zee KJ, Solin LJ, et al. Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ. J Clin Oncol. 2016 Nov 20;34(33):4040-6. [Reaffirmed 2019.]Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Diagnósticos diferenciais
- Invasive breast cancer
- Atypical hyperplasia
- Fibroadenoma
Mais Diagnósticos diferenciaisDiretrizes
- NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis
- NCCN clinical practice guidelines in oncology: breast cancer risk reduction
Mais DiretrizesFolhetos informativos para os pacientes
Breast cancer: DCIS (very early breast cancer) in women
Breast cancer, locally advanced: what is it?
Mais Folhetos informativos para os pacientesConectar-se ou assinar para acessar todo o BMJ Best Practice
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