Last reviewed: 24 Oct 2020
Last updated: 11 Sep 2020

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • jaundice
  • pallor
  • dark urine

Risk factors

  • male sex
  • neonate
  • ethnic origin in the Mediterranean, sub-Saharan Africa, Middle East, or Southeast Asia
  • family history
  • recent exposure to oxidative drugs
  • infection
  • recent exposure to broad beans (favism)

Diagnostic investigations

1st investigations to order

  • FBC
  • reticulocyte count
  • urinalysis
  • unconjugated (indirect) bilirubin
  • lactate dehydrogenase (LDH)
  • haptoglobin
  • peripheral blood smear
More 1st investigations to order

Investigations to consider

  • G6PD fluorescent spot test
  • G6PD spectrophotometry
  • genetic testing for G6PD variants
More investigations to consider

Emerging tests

  • G6PD rapid diagnostic testing
More emerging tests

Treatment algorithm

Contributors

Professor of Haematology and Consultant Haematologist

Royal Free Hospital and University College London School of Medicine

London

UK

Disclosures

ABM declares that he has no competing interests.

Peer reviewersVIEW ALL

Professor of Hematology

University of Firenze

Florence

Italy

Disclosures

LL declares that he has no competing interests.

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