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Central sleep apnoea

Última revisão: 10 Aug 2025
Última atualização: 24 Dec 2024

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presence of risk factors
  • insomnia, especially sleep-maintenance insomnia
  • poor concentration and attention span
  • observed periodic breathing or cessation of breathing or snoring during sleep (by partner)
  • transient dyspnoea that awakens from sleep or prevents sleep onset
  • headaches upon waking
  • complaints of poorly restorative sleep and/or daytime sleepiness
  • periodic breathing during wakefulness
Detalhes completos

Outros fatores diagnósticos

  • abnormal heart rhythm or the presence of third or fourth heart sounds
  • focal abnormality on neurological examination
  • neuromuscular weakness
  • history of endocrine disorders
Detalhes completos

Fatores de risco

  • congestive heart failure
  • stroke
  • renal failure
  • male sex
  • atrial fibrillation
  • age ≥60 years
  • opioid use
  • brainstem lesions
  • neuromuscular weakness
  • acromegaly
  • hypothyroidism
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • overnight polysomnography
Detalhes completos

Investigações a serem consideradas

  • serum thyroid stimulating hormone
  • serum creatinine
  • ECG
  • serum insulin-like growth factor 1 (acromegaly testing)
  • echocardiogram
Detalhes completos

Algoritmo de tratamento

AGUDA

without Cheyne-Stokes breathing: due to medical disorder

without Cheyne-Stokes breathing: primary (idiopathic)

with Cheyne-Stokes breathing

due to high-altitude periodic breathing

due to medication or substance misuse

treatment-emergent CSA

Colaboradores

Autores

Bernardo J. Selim, MD

Associate Professor of Medicine

Director of Respiratory Care Unit

Division of Pulmonary, Critical Care, and Sleep Medicine

Mayo Clinic

Rochester

MN

Declarações

BJS declares that he has no competing interests.

Lauren A. Tobias, MD

Assistant Professor of Medicine

Yale University School of Medicine

Department of Internal Medicine

Section of Pulmonary, Critical Care and Sleep Medicine

New Haven

CT

Declarações

LAT declares that she has no competing interests.

Agradecimentos

Dr Bernardo J. Selim and Dr Lauren A. Tobias would like to gratefully acknowledge Dr J. Shirine Allam, Dr Timothy I. Morgenthaler, and Dr Christine H. Won, previous contributors to this topic.

Declarações

JSA and TIM declare that they have no competing interests. CHW declares that she has been a speaker for Respironics CME.

Revisores

Teofilo Lee-Chiong, MD

National Jewish Medical and Research Center

Denver

CO

Declarações

TLC has been reimbursed by the American College of Chest Physicians (ACCP), American Academy of Sleep Medicine, American Thoracic Society, and Cephalon, the manufacturer of modafinil, for attending several conferences. He has been paid by the ACCP for running educational programs and by Elsevier for serving as consultant of the Sleep Medicine Clinics. He has also received research funding from the National Institutes of Health, Respironics, Restore, and Schwarz Pharma, and has been a member of the speakers' bureau for GlaxoSmithKline.

John A. Fleetham, MD, FRCP

Professor

University of British Columbia

Vancouver

Canada

Declarações

JAF declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

American Academy of Sleep Medicine. The AASM international classification of sleep disorders - third edition, text revision (ICSD-3-TR). Jun 2023 [internet publication].Texto completo

Randerath W, Verbraecken J, Andreas S, et al. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. Eur Respir J. 2017 Jan;49(1):1600959.Texto completo  Resumo

Mayer G, Arzt M, Braumann B, et al. German S3 guideline nonrestorative sleep/sleep disorders, chapter "sleep-related breathing disorders in adults," short version: German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM). Somnologie (Berl). 2017;21(4):290-301.Texto completo  Resumo

Aurora RN, Bista SR, Casey KR, et al. Updated adaptive servo-ventilation recommendations for the 2012 AASM guideline: "The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses". J Clin Sleep Med. 2016 May 15;12(5):757-61.Texto completo  Resumo

Aurora RN, Chowdhuri S, Ramar K, et al. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. Sleep. 2012 Jan 1;35(1):17-40.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Diagnósticos diferenciais

    • Obstructive sleep apnoea
    • Sleep-related hypoventilation/hypoxaemic syndromes
    • Depression
    Mais Diagnósticos diferenciais
  • Diretrizes

    • International classification of sleep disorders, 3rd edition, text revision (ICSD-3-TR)
    • Sleep-disordered breathing and cardiac arrhythmias in adults: mechanistic insights and clinical implications: a scientific statement from the American Heart Association
    Mais Diretrizes
  • Folhetos informativos para os pacientes

    Sleep apnoea in adults (obstructive)

    Mais Folhetos informativos para os pacientes
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