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Granuloma annulare

Última revisión: 19 Aug 2025
Última actualización: 26 Nov 2020

Resumen

Definición

Anamnesis y examen

Principales factores de diagnóstico

  • asymptomatic grouped annular pink or flesh-colored dermal papules
Todos los datos

Otros factores de diagnóstico

  • flesh-colored, pink, or brown macules or small papules
  • soft-tissue nodules
  • perforating papules, crusting or ulcerated lesions
  • erythematous patches
Todos los datos

Factores de riesgo

  • diabetes mellitus
  • hematologic malignancy
  • herpes zoster
  • HIV
  • hepatitis
  • hyperlipidemia
  • thyroid disease
  • medications
Todos los datos

Pruebas diagnósticas

Primeras pruebas diagnósticas para solicitar

  • clinical diagnosis
Todos los datos

Pruebas diagnósticas que deben considerarse

  • skin biopsy
  • fasting blood sugar
  • thyroid function tests
  • lipid screening
  • hepatitis screen
  • HIV testing
Todos los datos

Algoritmo de tratamiento

Agudo

localized variant (classic annular rash)

generalized variant (widespread macular rash)

perforating variant (crusted or ulcerated lesion)

subcutaneous variant (soft nodule)

patch variant (erythematous plaques)

Colaboradores

Autores

Misha Rosenbach, MD

Associate Professor

Dermatology and Internal Medicine

University of Pennsylvania

Philadelphia

PA

Divulgaciones

MR has received consulting fees from Merck, aTyr Pharma, and Processa Pharma, not related to granuloma annulare. He has received grant support from Processa Pharma, not related to granuloma annulare. MR has received salary support from the AMA/JAMA for his role at JAMA Dermatology as Deputy Editor. MR is an author of references cited in this topic.

Agradecimientos

Dr Misha Rosenbach would like to gratefully acknowledge Dr Susmita Mukherjee, a previous contributor to this topic. SM declares that she has no competing interests.

同行评议者

Aisha Sethi, MD

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

利益声明

AS declares that she has no competing interests.

Robert Herd, MSc, MD, FRCP

Consultant Dermatologist

Department of Dermatology

Nuffield Hospital

Glasgow

UK

利益声明

RH declares that he has no competing interests.

Brenda L. Pellicane, MD

Dermatologist

Wayne State University School of Medicine

Department of Dermatology

Detroit

MI

利益声明

BLP declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

参考文献

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

关键文献

Piette EW, Rosenbach M. Granuloma annulare: clinical and histologic variants, epidemiology, and genetics. J Am Acad Dermatol. 2016 Sep;75(3):457-65. 摘要

Thornsberry LA, English JC 3rd. Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. Am J Clin Dermatol. 2013 Aug;14(4):279-90. 摘要

Piette EW, Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016 Sep;75(3):467-79. 摘要

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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