Inflammation of the angles of the mouth, characterised by fissures, scaling, erythema, and crusting.
Aetiology is multi-factorial and includes mechanical factors, infectious agents, nutritional deficiencies, or inflammatory dermatological conditions.
Diagnosis is made clinically; however, laboratory tests help to identify aetiology.
Successful therapy is based on identifying and correcting each and all factors of this multi-factorial condition.
Angular cheilitis is inflammation of the angles of the mouth, characterised by fissures, scaling, erythema, and crusting.  The cause is usually multi-factorial, due either to a primary infection or to a non-infectious entity such as mechanical irritation, nutritional deficiency, or other dermatological condition. 
Professor and Vice Chair
Department of Family and Community Medicine
University of Kentucky College of Medicine
WCG declares that she has no competing interests.
Dr Wanda C. Gonsalves would like to gratefully acknowledge Dr Alison Bruce and Dr Kelly R. Tierney, previous contributors to this topic. AB and KRT declare that they have no competing interests.
Department of Dermatology
Wake Forest University School of Medicine
ADL declares that he has no competing interests.
Assistant Professor of Medicine
Associate Residency Program Director
University of Chicago
AS declares that she has no competing interests.
Use of this content is subject to our disclaimer