Bacterial meningitis

Overview 
Theory 
Diagnosis 
Management 
Follow up 
Resources 

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Observe que as formulações/vias e doses podem diferir entre nomes e marcas de medicamentos, formulários de medicamentos ou localidades. As recomendações de tratamento são específicas para os grupos de pacientes:ver aviso legal

Inicial

≤1 month of age and immunocompetent

1ª linha – empiric antibiotic therapy

Back

1ª linha –

empiric antibiotic therapy

Until the causative organism and its sensitivities have been identified, broad-spectrum antimicrobials should be given as soon as possible parenterally.[9][99][104]

The choice of empiric antibiotic depends on the patient's age and conditions that may have predisposed the patient to meningitis.[107] The regimen chosen must be broad enough to cover the potential organisms for the age group affected, with consideration for regional susceptibility rates.[59]

The recommended regimen is ampicillin plus cefotaxime.[59][104][107] If a cephalosporin cannot be administered (e.g., patients with an allergy), an alternative regimen for neonates is ampicillin plus an aminoglycoside (e.g., gentamicin).[59]

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to causative organism and its susceptibilities.[9][107]

Opções primárias

ampicillin: consult specialist for guidance on neonatal dose

cefotaxime: consult specialist for guidance on neonatal dose

Opções secundárias

ampicillin: consult specialist for guidance on neonatal dose

gentamicin: consult specialist for guidance on neonatal dose

associado a – supportive therapy

>1 month and <50 years of age and immunocompetent

1ª linha – empiric antibiotic therapy

Back

1ª linha –

empiric antibiotic therapy

Until the causative organism and its sensitivities have been identified, broad-spectrum antimicrobials should be given as soon as possible parenterally.[9][99][104]

The recommended regimen is cefotaxime or ceftriaxone plus vancomycin.[59][104][107] If a cephalosporin cannot be administered (e.g., patients with an allergy), a carbapenem (e.g., meropenem) plus vancomycin can be considered.[1][108]

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to causative organism and its susceptibilities.[9][107]

Opções primárias

vancomycin: children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

Mais

--E--

ceftriaxone: children: 80-100 mg/kg/day intravenously given in divided doses every 12-24 hours, maximum 4 g/day; adults: 2 g intravenously every 12 hours

cefotaxime: children: 200-300 mg/kg/day intravenously given in divided doses every 6-8 hours, maximum 12 g/day; adults: 2 g intravenously every 4-6 hours

Opções secundárias

vancomycin: children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

Mais

meropenem: children ≥3 months of age and <50 kg body weight: 40 mg/kg intravenously every 8 hours, maximum 6 g/day; children ≥3 months of age and ≥50 kg body weight and adults: 2 g intravenously every 8 hours

加 – supportive therapy

考虑 – dexamethasone

Back

考虑 –

dexamethasone

针对特定患者群中部分患者治疗的附加建议

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

In the US, the Infectious Diseases Society of America recommends that dexamethasone be started immediately prior to, or in conjunction with, the first dose of antibiotics and continued for 2-4 days.[6][108] European and UK guidelines recommend starting dexamethasone shortly before or in conjunction with antibiotics, or within 4-12 hours if already commenced, respectively.[64][108]

Once the causative organism is isolated, the use of dexamethasone should be reviewed; guidelines recommend that it is only continued for bacterial meningitis caused by pneumococcus or Haemophilus influenzae type b (Hib) as these have the strongest evidence for benefit.[107][108][111]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111] An observational study of 1391 adults with community-acquired bacterial meningitis also showed that the proportion of patients with unfavorable outcomes was lower in individuals treated with adjunctive dexamethasone in patients with nonpneumococcal and non- Haemophilus meningitis (with the exception of Listeria).[112]

In children, studies have shown corticosteroids likely reduce severe hearing loss in patients with Hib meningitis, but not necessarily in children with meningitis due to non- Haemophilus species.[113] In one meta-analysis of clinical studies published during 1988-1996, adjunctive dexamethasone had confirmed benefit for Hib meningitis and, if commenced with or before antimicrobial therapy, suggested benefit for pneumococcal meningitis in children.[114] One more recent large meta-analysis found administration of low-dose corticosteroids to be beneficial in children in reducing hearing loss and neurologic sequelae, as well as reducing the mean number of days before resolution of fever.[115]

The use of adjunctive dexamethasone in Listeria meningitis is controversial, and until more studies are performed it is not recommended.[117][118]

第一选择

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

≥50 years of age or immunocompromised

一线治疗 – empiric antibiotic therapy

Back

一线治疗 –

empiric antibiotic therapy

Until the causative organism and antibiotic sensitivities have been identified, broad-spectrum antimicrobials should be given as soon as possible parenterally.[9][99][104]

The recommended regimen is ampicillin plus cefotaxime or ceftriaxone plus vancomycin.[59][104][107] If ampicillin cannot be administered (e.g., patients with an allergy), trimethoprim/sulfamethoxazole could be considered as an alternative in place of ampicillin (excluding newborns where specialist advice should be sought).[1][107]

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to the causative organism and its susceptibilities.[9][107]

第一选择

ampicillin: neonates: consult specialist for guidance on dose; children: 200-400 mg/kg/day intravenously given in divided doses every 4-6 hours, maximum 12 g/day; adults: 1-2 g intravenously every 3-4 hours

-- 和 --

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

-- 和 --

ceftriaxone: neonates: consult specialist for guidance on dose; children: 80-100 mg/kg/day intravenously given in divided doses every 12-24 hours, maximum 4 g/day; adults: 2 g intravenously every 12 hours

或

cefotaxime: neonates: consult specialist for guidance on dose; children: 200-300 mg/kg/day intravenously given in divided doses every 6-8 hours, maximum 12 g/day; adults: 2 g intravenously every 4-6 hours

第二选择

sulfamethoxazole/trimethoprim: children ≥2 months of age and adults: 10-20 mg/kg/day intravenously given in divided doses every 6-12 hours

-- 和 --

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults:15-20 mg/kg intravenously every 8-12 hours

-- 和 --

或

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

Show drug information for a patient with no comorbidities

第一选择

ampicillin

-- 和 --

vancomycin

-- 和 --

ceftriaxone

或

cefotaxime

第二选择

sulfamethoxazole/trimethoprim

-- 和 --

vancomycin

-- 和 --

ceftriaxone

或

cefotaxime

加 – supportive therapy

Plus – dexamethasone

Back

Plus –

dexamethasone

Treatment recommended for ALL patients in selected patient group

Ideally dexamethasone should be given to all patients who present with clinical features of bacterial meningitis.[6][64][104][109]

Once the causative organism is isolated, the use of dexamethasone should be reviewed; guidelines recommend that it is only continued for bacterial meningitis caused by pneumococcus or Haemophilus influenzae type b as these have the strongest evidence for benefit.[107][108][111]

The use of adjunctive dexamethasone in Listeria meningitis is controversial, and until more studies are performed it is not recommended.[117][118]

Dexamethasone generally should not be withheld in immunocompromised patients. In studies where it has been given to patients with bacterial meningitis, including those with Listeria, mortality tended to be lower in those on adjunctive dexamethasone therapy as compared to those without dexamethasone therapy.[108][110]

第一选择

dexamethasone sodium phosphate: 10 mg intravenously every 6 hours

急症处理

confirmed infection: Streptococcus pneumoniae

penicillin-susceptible

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to the causative organism and its susceptibilities.[9][107] Typically, the duration of antibacterial treatment depends on the clinical response and the cerebrospinal fluid microbiologic response after treatment has started.

Penicillin-susceptible Streptococcus pneumoniae (i.e., minimum inhibitory concentration <0.06 microgram/mL) should be treated with penicillin-G or ampicillin. Alternatives include a third-generation cephalosporin (e.g., ceftriaxone).[107]

Treatment course: 10-14 days.

Primary options

penicillin G potassium: neonates: consult specialist for guidance on dose; children: 250,000 to 400,000 units/kg/day intravenously given in divided doses every 4-6 hours, maximum 24 million units/day; adults: 2 million units intravenously every 2 hours

Secondary options

Plus – supportive therapy

Consider – dexamethasone

Back

Consider –

dexamethasone

Treatment recommended for SOME patients in selected patient group

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

Once the causative organism is isolated, the use of dexamethasone should be reviewed; guidelines recommend that dexamethasone be continued for bacterial meningitis caused by pneumococcus.[107][108][111]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111]

In children, studies have shown corticosteroids have suggested benefit in pneumococcal meningitis.[114] In one meta-analysis of clinical studies published during 1988-1996, adjunctive dexamethasone had confirmed benefit for Haemophilus influenzae type b meningitis and, if commenced with or before antimicrobial therapy, suggested benefit for pneumococcal meningitis in children.[114]

One more recent large meta-analysis found administration of low-dose corticosteroids to be beneficial in children in reducing hearing loss and neurologic sequelae, as well as reducing the mean number of days before resolution of fever.[115]

Corticosteroids are not currently recommended in neonates.[59]

Primary options

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

penicillin-intermediate sensitivity

1st line – targeted antibiotic therapy

Back

1st line –

targeted antibiotic therapy

Penicillin-intermediate Streptococcus pneumoniae (i.e., minimum inhibitory concentration ≥0.12 microgram/mL) or ceftriaxone-intermediate (MIC <1 microgram/mL) should be treated with cefotaxime or ceftriaxone. Alternatives include a carbapenem (e.g., meropenem) or a fourth-generation cephalosporin (e.g., cefepime).[107]

Treatment course: 10-14 days.

第一选择

或

第二选择

或

cefepime: children ≥2 months of age: 150 mg/kg/day intravenously given in divided doses every 8 hours; adults: 2 g intravenously every 8 hours

加 – supportive therapy

考虑 – dexamethasone

Back

考虑 –

dexamethasone

针对特定患者群中部分患者治疗的附加建议

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111]

Corticosteroids are not currently recommended in neonates.[59]

第一选择

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

penicillin-resistant

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to the causative organism and its susceptibilities.[9][99]

Penicillin-resistant Streptococcus pneumoniae (minimum inhibitory concentration [MIC] ≥2.0 micrograms/mL) or cephalosporin-resistant organisms (MIC ≥1.0 microgram/mL) should be treated with vancomycin plus cefotaxime or ceftriaxone. Alternatives include vancomycin plus a fluoroquinolone (e.g., levofloxacin, moxifloxacin).[107][108][137]

Systemic fluoroquinolone antibiotics may cause serious, disabling, and potentially long-lasting or irreversible adverse events. This includes, but is not limited to: tendinopathy/tendon rupture; peripheral neuropathy; arthropathy/arthralgia; aortic aneurysm and dissection; heart valve regurgitation; dysglycemia; and central nervous system effects including seizures, depression, psychosis, and suicidal thoughts and behavior.[144] Prescribing restrictions apply to the use of fluoroquinolones, and these restrictions may vary between countries. In general, fluoroquinolones should be restricted for use in serious, life-threatening bacterial infections only. Some regulatory agencies may also recommend that they must only be used in situations where other antibiotics, that are commonly recommended for the infection, are inappropriate (e.g., resistance, contraindications, treatment failure, unavailability). Consult your local guidelines and drug information source for more information on suitability, contraindications, and precautions.

Treatment course: 10-14 days.

第一选择

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

-- 和 --

或

第二选择

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

-- 和 --

levofloxacin: children: consult specialist for guidance on dose; adults 750 mg intravenously every 24 hours

或

moxifloxacin: children: consult specialist for guidance on dose; adults 400 mg intravenously every 24 hours

加 – supportive therapy

考虑 – dexamethasone

Back

考虑 –

dexamethasone

针对特定患者群中部分患者治疗的附加建议

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111]

Corticosteroids are not currently recommended in neonates.[59]

第一选择

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

confirmed infection: Haemophilus influenzae

beta-lactamase-negative

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Haemophilus influenzae beta lactamase negative patients should be treated with ampicillin. Alternatives include a third- or fourth-generation cephalosporin (e.g., ceftriaxone, cefepime) or a fluoroquinolone (e.g., levofloxacin, ciprofloxacin).[107]

Treatment course: 7-10 days.

第一选择

第二选择

或

cefepime: children ≥2 months of age: 150 mg/kg/day intravenously given in divided doses every 8 hours; adults: 2 g intravenously every 8 hours

或

levofloxacin: children: consult specialist for guidance on dose; adults 750 mg intravenously every 24 hours

或

ciprofloxacin: children: consult specialist for guidance on dose; adults 400 mg intravenously every 8-12 hours

加 – supportive therapy

考虑 – dexamethasone

Back

考虑 –

dexamethasone

针对特定患者群中部分患者治疗的附加建议

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111]

In children, studies have shown corticosteroids likely reduce severe hearing loss in patients with Hib meningitis.[113][114]

One large meta-analysis found administration of low-dose corticosteroids to be beneficial in children in reducing hearing loss and neurologic sequelae, as well as reducing the mean number of days before resolution of fever.[115]

Corticosteroids are not currently recommended in neonates.[59]

第一选择

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

beta-lactamase-positive

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Haemophilus influenzae beta-lactamase-positive patients should be treated with cefotaxime or ceftriaxone. Alternatives include a fourth-generation cephalosporin (e.g., cefepime) or a fluoroquinolone (e.g., levofloxacin, ciprofloxacin).[107]

Treatment course: 10-14 days.

第一选择

或

第二选择

cefepime: children ≥2 months of age: 150 mg/kg/day intravenously given in divided doses every 8 hours; adults: 2 g intravenously every 8 hours

或

levofloxacin: children: consult specialist for guidance on dose; adults 750 mg intravenously every 24 hours

或

ciprofloxacin: children: consult specialist for guidance on dose; adults 400 mg intravenously every 8-12 hours

加 – supportive therapy

考虑 – dexamethasone

Back

考虑 –

dexamethasone

针对特定患者群中部分患者治疗的附加建议

Ideally dexamethasone should be given to all patients older than 6 weeks who present with clinical features of bacterial meningitis.[6][64][104][109]

Evidence suggests that there is benefit from high-dose dexamethasone in reducing mortality and hearing impairment in adults with bacterial meningitis.[111]

In children, studies have shown corticosteroids likely reduce severe hearing loss in patients with Hib meningitis.[113][114]

Corticosteroids are not currently recommended in neonates.[59]

第一选择

dexamethasone sodium phosphate: children >6 weeks of age: 0.15 mg/kg intravenously every 6 hours; adults: 10 mg intravenously every 6 hours

confirmed infection: Streptococcus agalactiae (group B streptococci)

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Streptococcus agalactiae (group B streptococci) should be treated with either ampicillin or penicillin-G. Alternatives include a third-generation cephalosporin (e.g., ceftriaxone, cefotaxime) or vancomycin.[107]

Treatment course: 14-21 days.

第一选择

或

第二选择

或

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

加 – supportive therapy

confirmed infection: Escherichia coli and other gram-negative Enterobacteriaceae

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Escherichia coli and other gram-negative Enterobacteriaceae should be treated with ceftriaxone or cefotaxime. Alternatives include aztreonam, a fluoroquinolone (e.g., ciprofloxacin), trimethoprim/sulfamethoxazole, meropenem, or ampicillin.[107][108]

Treatment course: 21-28 days.

第一选择

或

第二选择

或

aztreonam: neonates: consult specialist for guidance on dose; children: 120-200 mg/kg/day intravenously given in divided doses every 6-8 hours, maximum 8 g/day, adults: 2 g intravenously every 6-8 hours

或

ciprofloxacin: children: consult specialist for guidance on dose; adults 400 mg intravenously every 8-12 hours

或

sulfamethoxazole/trimethoprim: children ≥2 months of age and adults: 10-20 mg/kg/day intravenously given in divided doses every 6-12 hours

或

加 – supportive therapy

confirmed infection: Listeria monocytogenes

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to the causative organism and antibiotic susceptibilities.[9][107] Typically, the duration of antibacterial treatment depends on the clinical response and the cerebrospinal fluid microbiologic response after treatment has started.

Listeria monocytogenes should be treated with gentamicin plus ampicillin or penicillin-G.[107][108] Alternatives include trimethoprim/sulfamethoxazole.

Treatment course: 21-28 days.

第一选择

gentamicin: neonates: consult specialist for guidance on dose; children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

-- 和 --

或

第二选择

sulfamethoxazole/trimethoprim: children ≥2 months of age and adults: 10-20 mg/kg/day intravenously given in divided doses every 6-12 hours

加 – supportive therapy

confirmed infection: Staphylococcus aureus

methicillin-susceptible

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Staphylococcus aureus that is methicillin-susceptible should be treated with nafcillin or oxacillin. Alternatives include vancomycin, linezolid, or daptomycin.[107][108]

Treatment course: depends on microbiologic response of cerebrospinal fluid and underlying illness.

第一选择

nafcillin: neonates: consult specialist for guidance on dose; children: 200 mg/kg/day intravenously given in divided doses every 6 hours, maximum 12 g/day; adults: 2 g intravenously every 4 hours

或

oxacillin: neonates: consult specialist for guidance on dose; children: 200 mg/kg/day intravenously given in divided doses every 6 hours, maximum 12 g/day; adults: 2 g intravenously every 4 hours

第二选择

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

或

linezolid: neonates: consult specialist for guidance on dose; children: 10 mg/kg intravenously every 8 hours, maximum 600 mg/dose; adults: 600 mg intravenously every 12 hours

或

daptomycin: children: consult specialist for guidance on dose; adults: 6-10 mg/kg intravenously every 24 hours

加 – supportive therapy

methicillin-resistant

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Staphylococcus aureus that is methicillin-resistant should be treated with vancomycin. Alternatives include trimethoprim/sulfamethoxazole, linezolid, or daptomycin.[107][108]

Treatment course: depends on microbiologic response of cerebrospinal fluid and underlying illness.

第一选择

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

第二选择

sulfamethoxazole/trimethoprim: children ≥2 months of age and adults: 10-20 mg/kg/day intravenously given in divided doses every 6-12 hours

或

linezolid: neonates: consult specialist for guidance on dose; children: 10 mg/kg intravenously every 8 hours, maximum 600 mg/dose; adults: 600 mg intravenously every 12 hours

或

daptomycin: children: consult specialist for guidance on dose; adults: 6-10 mg/kg intravenously every 24 hours

加 – supportive therapy

confirmed infection: Staphylococcus epidermidis

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Staphylococcus epidermidis should be treated with vancomycin. Alternatives include linezolid.[108][138]

Treatment course: depends on microbiologic response of cerebrospinal fluid and underlying illness.

第一选择

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

第二选择

linezolid: neonates: consult specialist for guidance on dose; children: 10 mg/kg intravenously every 8 hours, maximum 600 mg/dose; adults: 600 mg intravenously every 12 hours

加 – supportive therapy

confirmed infection: Pseudomonas aeruginosa

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Pseudomonas aeruginosa should be treated with ceftazidime. Alternatives include meropenem.[108][139][140]

Treatment course: 21 days.

第一选择

ceftazidime sodium: neonates: consult specialist for guidance on dose; children: 150-200 mg/kg/day intravenously given in divided doses every 6-8 hours, maximum 6 g/day; adults: 2 g intravenously every 8 hours

第二选择

加 – supportive therapy

confirmed infection: Enterococcus species

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

After diagnosis is confirmed (generally within 12-48 hours of admission to the hospital), antimicrobial therapy can be modified according to the causative organism and antibiotic susceptibilities.[9][99] Typically, the duration of antibacterial treatment depends on the clinical response and the cerebrospinal fluid microbiologic response after treatment has started.

Enterococcus species should be treated with ampicillin plus gentamicin.[99][141][142] Alternatives include vancomycin plus gentamicin (if ampicillin resistant), or linezolid (if ampicillin and vancomycin resistant).[108]

Treatment course: 21 days.

第一选择

gentamicin: neonates: consult specialist for guidance on dose; children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

和

第二选择

gentamicin: neonates: consult specialist for guidance on dose; children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

和

vancomycin: neonates: consult specialist for guidance on dose; children: 15 mg/kg intravenously every 6 hours; adults: 15-20 mg/kg intravenously every 8-12 hours

或

linezolid: neonates: consult specialist for guidance on dose; children: 10 mg/kg intravenously every 8 hours, maximum 600 mg/dose; adults: 600 mg intravenously every 12 hours

加 – supportive therapy

confirmed infection: Acinetobacter species

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Acinetobacter species should be treated with meropenem with or without gentamicin. An alternative regimen (in cases of resistance) includes polymyxin B (given intrathecally) plus an aminoglycoside with or without rifampin.[143]

Treatment course: 21 days.

第一选择

或

和

gentamicin: children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

第二选择

polymyxin B: children <2 years of age: 25,000 units intrathecally once daily on alternate days; children ≥2 years of age: 50,000 units intrathecally once daily for 3-4 days, followed by 50,000 units once daily on alternate days; adults: 50,000 units intrathecally once daily

和

gentamicin: neonates: consult specialist for guidance on dose; children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

或

和

gentamicin: neonates: consult specialist for guidance on dose; children: 2 mg/kg intravenously every 8 hours; adults: 1 mg/kg intravenously every 8 hours

和

rifampin: children: consult specialist for guidance on dose; adults: 600 mg intravenously every 12 hours

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

Show drug information for a patient with no comorbidities

第一选择

meropenem

或

meropenem

和

gentamicin

第二选择

polymyxin B

和

gentamicin

或

polymyxin B

和

gentamicin

和

rifampin

加 – supportive therapy

confirmed infection: Neisseria meningitidis

penicillin-susceptible

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Neisseria meningitidis that is penicillin-susceptible (MIC <0.1 microgram/mL) should be treated with ampicillin or penicillin-G. Alternatives include a third-generation cephalosporin (e.g., ceftriaxone).[107][108]

Treatment course: 7 days.

第一选择

或

第二选择

加 – supportive therapy

penicillin-intermediate sensitivity

一线治疗 – targeted antibiotic therapy

Back

一线治疗 –

targeted antibiotic therapy

Neisseria meningitidis that is penicillin-intermediate susceptible (MIC=0.1 to 1.0 microgram/mL) should be treated with cefotaxime or ceftriaxone. Alternatives include a fluoroquinolone (e.g., levofloxacin, ciprofloxacin) or meropenem.[107][108]

Treatment course: 7 days.

第一选择

或

第二选择

或

levofloxacin: children: consult specialist for guidance on dose; adults 750 mg intravenously every 24 hours

或

ciprofloxacin: children: consult specialist for guidance on dose; adults 400 mg intravenously every 8-12 hours

加 – supportive therapy

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Bacterial meningitis

Algoritmo de tratamento

≤1 month of age and immunocompetent

empiric antibiotic therapy

Opções primárias

Opções secundárias

These drug options and doses relate to a patient with no comorbidities.

Opções primárias

Opções secundárias

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

Opções primárias

Opções secundárias

supportive therapy

>1 month and <50 years of age and immunocompetent

empiric antibiotic therapy

Opções primárias

Opções secundárias

These drug options and doses relate to a patient with no comorbidities.

Opções primárias

第二选择

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

第一选择

第二选择

supportive therapy

dexamethasone

第一选择

These drug options and doses relate to a patient with no comorbidities.

第一选择

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

第一选择

≥50 years of age or immunocompromised

empiric antibiotic therapy

第一选择

第二选择

These drug options and doses relate to a patient with no comorbidities.

第一选择

第二选择

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

第一选择

第二选择

supportive therapy

dexamethasone

第一选择

These drug options and doses relate to a patient with no comorbidities.

第一选择

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

第一选择

confirmed infection: Streptococcus pneumoniae

penicillin-susceptible

targeted antibiotic therapy

Primary options

Secondary options

These drug options and doses relate to a patient with no comorbidities.

Primary options

Secondary options

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

Primary options

Secondary options

supportive therapy

dexamethasone

Primary options

These drug options and doses relate to a patient with no comorbidities.

Primary options

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

Primary options

penicillin-intermediate sensitivity

targeted antibiotic therapy

第一选择

第二选择

These drug options and doses relate to a patient with no comorbidities.

第一选择

第二选择

Drug choice, dose and interactions may be affected by the patient's comorbidities. Check your local drug formulary.

第一选择

第二选择

supportive therapy

dexamethasone

第一选择

These drug options and doses relate to a patient with no comorbidities.

第一选择