Last reviewed: 5 Jul 2021
Last updated: 01 Jul 2021

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • asymptomatic

Other diagnostic factors

  • cervical discharge
  • friable cervix
  • abnormal vaginal bleeding
  • penile discharge
  • vaginal discharge
  • dysuria
  • pelvic pain
  • fever/chills
  • nausea/vomiting
  • scrotal pain
  • myalgias
  • abdominal pain
  • mucopurulent rectal discharge or tenesmus
  • joint pain and swelling
  • eye irritation
  • rashes
  • inflammation

Risk factors

  • age under 25 years, sexually active
  • new sex partner or multiple sex partners
  • sexual activity with infected partner
  • condoms not used
  • history of prior STI
  • ethnicity
  • urban residence and low socio-economic status

Diagnostic investigations

Investigations to consider

  • direct immunofluorescence
  • enzyme immunoassay
  • nucleic acid hybridisation tests
  • cell culture

Emerging tests

  • rapid and point-of-care tests

Treatment algorithm

Contributors

Authors

Matthew M. Hamill, MBChB, PhD, FRCP

Assistant Professor of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

Disclosures

MMH receives royalties for contributing to UpToDate on Lymphogranuloma venereum.

Acknowledgements

Dr Matthew M. Hamill would like to gratefully acknowledge Dr Anne Rompalo and Dr Christopher K. Fairley, the previous contributors to this topic.

Disclosures

AR and CKF declare that they have no competing interests.

Peer reviewers

Kenneth Lin, MD

Assistant Editor

American Family Physician

Clinical Assistant Professor

GUSOM Medical Officer

US Preventive Services Task Force

Disclosures

KL declares that he has no competing interests.

Lars Jørgen Østergaard, MD, PhD, DMSc

Professor/Head

Department of Infectious Diseases

Aarhus University Hospital

Skejby Sygehus

Aarhus

Denmark

Disclosures

LJO has been funded by Pfizer to write a leaflet on Chlamydia infections.

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