Septic arthritis

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Last reviewed: 14 Feb 2025
Last updated: 22 Nov 2022

Summary

Definition

History and exam

Key diagnostic factors

  • hot, swollen, painful, restricted joint
  • acute presentation
Full details

Other diagnostic factors

  • fever
  • large joint
  • single joint
  • prosthetic joint
  • proportionality of symptoms
  • sexual activity
  • erythema migrans
  • risk factors
Full details

Risk factors

  • underlying joint disease
  • prosthetic joint
  • age
  • immunosuppression
  • contiguous spread
  • exposure to ticks
  • previous intra-articular corticosteroid injection
  • recent joint surgery
  • low socioeconomic status
Full details

Diagnostic investigations

1st investigations to order

  • synovial fluid microscopy, Gram stain, and polarising microscopy
  • synovial fluid culture and sensitivities
  • synovial fluid white cell count
  • blood culture and sensitivities
  • white cell count
  • erythrocyte sedimentation rate (ESR)
  • CRP
  • urea and electrolytes
  • LFTs
  • plain x-ray
  • ultrasound
Full details

Investigations to consider

  • procalcitonin (PCT)
  • MRI
  • synovial fluid polymerase chain reaction (PCR)
  • swabs for microscopy, culture, and sensitivity
  • urine dipstick, microscopy, culture, and sensitivity
  • enzyme-linked immunosorbent assay (ELISA)
  • synovial biopsy
Full details

Emerging tests

  • calprotectin
Full details

Treatment algorithm

INITIAL

suspected infection in any joint(s): systemic involvement

suspected infection in prosthetic joint(s): no systemic involvement

suspected infection in native joint(s): no systemic involvement

ACUTE

confirmed infection in any joint(s): systemic involvement

confirmed infection in prosthetic joint(s): no systemic involvement

confirmed infection in native joint(s): no systemic involvement

unconfirmed infection with clinically suspected infection in native joint(s): no systemic involvement

Contributors

Expert advisers

Alexander Alexiou, MB, BS, BSc, DCH, FRCEM, DipIMC RSEd

Consultant in Emergency Medicine

Royal London Hospital

Consultant in Physician Response Unit

Barts Health NHS Trust/London Air Ambulance

London

UK

Disclosures

AA declares that he has no competing interests.

Acknowledgements

BMJ Best Practice would like to gratefully acknowledge the previous expert contributors to this, whose work is retained in parts of the content:

Gerald Coakley PhD, FRCP

Consultant Rheumatologist

Queen Elizabeth Hospital

London

UK

GC is an author of a reference cited in this topic.

Catherine J. Mathews MSc, FRCP

Consultant Rheumatologist

Queen Elizabeth Hospital

London

UK

CJM is an author of a reference cited in this topic.

Johann Grundlingh

Emergency Medicine Consultant

Royal London Hospital

Barts Health NHS Trust

Honorary senior lecturer

Queen Mary University

London

UK

JG declares that he has no competing interests.

Theodore Young

CT1 anaesthetics

Anaesthetic Department

Peterborough City Hospital

Peterborough

UK

TY declares that he has no competing interests.

Peer reviewers

Catherine J. Mathews, MSc, FRCP

Consultant Rheumatologist

Lewisham and Greenwich NHS Trust

London

UK

Disclosures

CJM is an author of references cited in this topic.

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