Summary
Definition
History and exam
Key diagnostic factors
- hot, swollen, painful, restricted joint
- acute presentation
Other diagnostic factors
- fever
- large joint
- single joint
- prosthetic joint
- proportionality of symptoms
- sexual activity
- erythema migrans
- risk factors
Risk factors
- underlying joint disease
- prosthetic joint
- age
- immunosuppression
- contiguous spread
- exposure to ticks
- previous intra-articular corticosteroid injection
- recent joint surgery
- low socioeconomic status
Diagnostic investigations
1st investigations to order
- synovial fluid microscopy, Gram stain, and polarising microscopy
- synovial fluid culture and sensitivities
- synovial fluid white cell count
- blood culture and sensitivities
- white cell count
- erythrocyte sedimentation rate (ESR)
- CRP
- urea and electrolytes
- LFTs
- plain x-ray
- ultrasound
Investigations to consider
- procalcitonin (PCT)
- MRI
- synovial fluid polymerase chain reaction (PCR)
- swabs for microscopy, culture, and sensitivity
- urine dipstick, microscopy, culture, and sensitivity
- enzyme-linked immunosorbent assay (ELISA)
- synovial biopsy
Emerging tests
- calprotectin
Treatment algorithm
suspected infection in any joint(s): systemic involvement
suspected infection in prosthetic joint(s): no systemic involvement
suspected infection in native joint(s): no systemic involvement
confirmed infection in any joint(s): systemic involvement
confirmed infection in prosthetic joint(s): no systemic involvement
confirmed infection in native joint(s): no systemic involvement
unconfirmed infection with clinically suspected infection in native joint(s): no systemic involvement
Contributors
Expert advisers
Alexander Alexiou, MB, BS, BSc, DCH, FRCEM, DipIMC RSEd
Consultant in Emergency Medicine
Royal London Hospital
Consultant in Physician Response Unit
Barts Health NHS Trust/London Air Ambulance
London
UK
Disclosures
AA declares that he has no competing interests.
Acknowledgements
BMJ Best Practice would like to gratefully acknowledge the previous expert contributors to this, whose work is retained in parts of the content:
Gerald Coakley PhD, FRCP
Consultant Rheumatologist
Queen Elizabeth Hospital
London
UK
GC is an author of a reference cited in this topic.
Catherine J. Mathews MSc, FRCP
Consultant Rheumatologist
Queen Elizabeth Hospital
London
UK
CJM is an author of a reference cited in this topic.
Johann Grundlingh
Emergency Medicine Consultant
Royal London Hospital
Barts Health NHS Trust
Honorary senior lecturer
Queen Mary University
London
UK
JG declares that he has no competing interests.
Theodore Young
CT1 anaesthetics
Anaesthetic Department
Peterborough City Hospital
Peterborough
UK
TY declares that he has no competing interests.
Peer reviewers
Catherine J. Mathews, MSc, FRCP
Consultant Rheumatologist
Lewisham and Greenwich NHS Trust
London
UK
Disclosures
CJM is an author of references cited in this topic.
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