Last reviewed: 25 Oct 2020
Last updated: 29 May 2018



History and exam

Risk factors

  • family history of IgAN
  • male sex
  • age 20 to 30 years
  • Asian/white/native American ancestry
  • IgA vasculitis
  • chronic liver disease
  • HIV infection

Diagnostic investigations

1st investigations to order

  • urinalysis
  • urine microscopy and culture
  • basic biochemistry, including estimated glomerular filtration rate (GFR)
  • C3 and C4 complement levels
  • renal ultrasound
  • computed tomography (KUB)
  • renal biopsy
More 1st investigations to order

Treatment algorithm


The Mayer Professor of Renal Medicine

Department of Infection, Immunity & Inflammation

University of Leicester

Honorary Consultant Nephrologist

John Walls Renal Unit

Leicester General Hospital

Head of the Postgraduate Specialty School of Clinical Academic Training

Health Education East Midlands



JB has consultancies with Kancera AB, AduroBiotech, Anthera Pharmaceuticals, Calliditas, Novartis, Omeros, and EMD Serono. He is also an author of a number of references cited in this monograph.

Adjunct Assistant Professor

Deputy Head & Consultant

Department of Renal Medicine

Tan Tock Seng Hospital



SCY is an author of a reference cited in this monograph.

Dr Jonathan Barratt and Dr See Cheng Yeo would like to gratefully acknowledge Dr Hani Bleibel and Dr Chike Nzerue, previous contributors to this monograph. HB and CN declare that they have no competing interests.

Peer reviewersVIEW ALL

Associate Professor of Medicine

Nephrology Division

Stanford University Medical Center




RL declares that he has no competing interests.

Professor of Nephrology

UCL Centre for Nephrology

Royal Free Hospital




AS declares that he has no competing interests.

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