Last reviewed: April 2020
Last updated: January  2020

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • fever
  • rash
  • altered mental state
  • focal neurological deficit
  • meningismus
  • parotitis
  • lymphadenopathy
  • optic neuritis
  • acute flaccid paralysis
  • movement disorder

Other diagnostic factors

  • cough
  • gastrointestinal infection
  • seizures
  • biphasic illness
  • autonomic and hypothalamic disturbances
  • myocarditis/pericarditis
  • jaundice
  • arthritis
  • retinitis
  • parkinsonism

Risk factors

  • age <1 or >65 years
  • immunodeficiency
  • vaccination
  • post-infection
  • blood/body fluid exposure
  • organ transplantation
  • animal or insect bites
  • location
  • season
  • occupation
  • hunting/trekking in woods
  • swimming or diving in warm freshwater or nasal/sinus irrigation
  • spelunking (cave-exploring)
  • death in animals
  • cancer

Diagnostic investigations

1st investigations to order

  • FBC
  • peripheral blood smear
  • serum electrolytes
  • liver function tests
  • blood cultures
  • throat swab
  • nasopharyngeal aspirate
  • sputum culture
  • chest radiography
  • CT brain
  • MRI brain
  • electroencephalogram (EEG)
  • cerebrospinal fluid (CSF) analysis
  • CSF culture
  • CSF serology
  • CSF polymerase chain reaction (PCR)
More 1st investigations to order

Investigations to consider

  • urine culture
  • stool enteroviral culture
  • IgG and IgM antibodies (blood)
  • PCR (blood)
  • HIV serology/RNA test
  • CSF biomarkers/prion protein assay
  • paraneoplastic antibodies (blood and CSF)
  • whole-body CT
  • whole-body PET scans
  • magnetic resonance spectroscopy
  • next-generation sequencing of CSF
  • brain biopsy
More investigations to consider

Treatment algorithm

Contributors

Associate Professor 

Department of Neurology

University of Washington Medical Centre

Seattle

WA

Disclosures

LHW declares that he has no competing interests.

Clinical Pharmacist

University of California

Los Angeles

LA

Disclosures

LTW declares that she has no competing interests.

Clinical Instructor

Department of Neurology

Yale University 

New Haven

Connecticut

CT

Disclosures

PBP declares that she has no competing interests.

Dr Leo H. Wang, Dr Louise T. Wang, and Dr Payal B. Patel would like to gratefully acknowledge Dr Catalina C. Ionita, Dr Manjunath Markandaya, Dr David Janicke, Dr Robert Schmidt, and Dr Kimiko Domoto-Reilly, previous contributors to this topic. 

Peer reviewersVIEW ALL

Professor of Paediatric Neurology

The University of Sydney

Consultant Neurologist

The Children's Hospital at Westmead

Sydney

Australia

Disclosures

RD declares that he has no competing interests.

Associate Professor, Neurology

Director

Johns Hopkins Encephalitis Center

Johns Hopkins Hospital

Baltimore

MD

Disclosures

AV declares that he has no competing interests.

Use of this content is subject to our disclaimer