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Narcolepsy

Последний просмотренный: 18 May 2026
Last updated: 31 Jul 2024

Резюме

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • excessive daytime sleepiness
  • cataplexy
  • hypnagogic/hypnopompic hallucinations
  • sleep paralysis
Полная информация

Другие диагностические факторы

  • chronic fatigue or tiredness
  • poor performance at work
  • poor memory and concentration
  • car accidents
  • slurred speech
  • blurred vision
  • irregular breathing pattern
  • sleep attacks
  • fragmented nocturnal sleep
  • symptoms of other sleep disorders
  • obesity
  • status cataplecticus
  • hepatomegaly
  • paresis
Полная информация

Факторы риска

  • low cerebrospinal fluid hypocretin
  • human leukocyte antigen (HLA)-DQB1*0602
  • Prader-Willi syndrome
  • Niemann-Pick disease type C
  • linkage to 4p13-q21
  • genes on chromosome 6 or chromosome 21
  • hypothalamic tumors
  • hypothalamic infarct/hemorrhage
  • head trauma
  • central nervous system infection
  • central nervous system arteriovenous malformations
  • multiple sclerosis
  • myotonic dystrophy
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • actigraphy and sleep diary
  • overnight polysomnography
  • multiple sleep latency test (MSLT)
Полная информация

Исследования, проведение которых нужно рассмотреть

  • HLA typing
  • cerebrospinal fluid hypocretin-1 level
  • maintenance of wakefulness test
Полная информация

Алгоритм лечения

ПРОДОЛЖЕНИЕ

adults with excessive daytime sleepiness (EDS)

adults with cataplexy

children with excessive daytime sleepiness (EDS)

children with cataplexy

Составители

Авторы

Octavian C. Ioachimescu, MD, PhD
Octavian C. Ioachimescu

Associate Professor

Emory University

Atlanta VA Medical Center

Atlanta

GA

Раскрытие информации

OCI is an editor of a book cited in this topic.

Рецензенты

Kumaraswamy Budur, MD

Medical Doctor

Sleep Disorders Center

Department of Psychiatry

Cleveland Clinic

Cleveland

OH

Раскрытие информации

KB declares that he has no competing interests.

Seiji Nishino, MD, PhD

Associate Professor

Psychiatry and Behavioral Science

Stanford University School of Medicine

Stanford

CA

Раскрытие информации

SN declares that he has no competing interests.

Kingman P. Strohl, MD, FCCP

Professor of Medicine

Director

Center for Sleep Disorders Research

Professor of Anatomy

Department of Medicine

Case Western Reserve University

Cleveland

OH

Раскрытие информации

KPS declares that he has no competing interests.

Paul Reading, MBBS

Consultant Neurologist

James Cook University Hospital

Middlesbrough

UK

Раскрытие информации

PR declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

American Academy of Sleep Medicine. The AASM International classification of sleep disorders – third edition, text revision (ICSD-3-TR). Jun 2023 [internet publication].Полный текст

Smith MT, McCrae CS, Cheung J, et al. Use of actigraphy for the evaluation of sleep disorders and circadian rhythm sleep-wake disorders: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2018 Jul 15;14(7):1231-7.Полный текст  Аннотация

Maski K, Trotti LM, Kotagal S, et al. Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2021 Sep 1;17(9):1881-93.Полный текст  Аннотация

Bassetti CLA, Kallweit U, Vignatelli L, et al. European guideline and expert statements on the management of narcolepsy in adults and children. Eur J Neurol. 2021 Sep;28(9):2815-30.Полный текст  Аннотация

Maski K, Trotti LM, Kotagal S, et al. Treatment of central disorders of hypersomnolence: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2021 Sep 1;17(9):1895-945.Полный текст  Аннотация

Статьи, указанные как источники

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