Evaluation of fever of unknown origin in adults

Last reviewed: 15 Aug 2025
Last updated: 31 Jul 2025

Summary

鉴别诊断

常见

  • Tuberculosis (TB)
  • Abdominal or pelvic abscess
  • HIV
  • Rhinosinusitis, acute or chronic
  • Bacterial pneumonia
  • Urinary tract infection
完整详情

不常见

  • Infective endocarditis
  • Dental abscesses
  • Osteomyelitis
  • Prostatitis, acute or chronic
  • Cytomegalovirus infection
  • Epstein-Barr virus infection
  • Coronavirus disease 2019 (COVID-19)
  • Rheumatic fever
  • Lyme disease
  • Chronic myeloid leukemia
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Metastatic carcinoma, primary unknown
  • Renal cancer
  • Myelodysplastic syndrome
  • Adult-onset Still disease
  • Polymyalgia rheumatica
  • Giant cell arteritis
  • Systemic lupus erythematosus
  • Crohn disease
  • Ulcerative colitis
  • Rheumatoid arthritis
  • Reactive arthritis
  • Drug-induced fever
  • Cirrhosis, complicated
  • Hepatitis
  • Deep vein thrombosis
  • Sarcoidosis
  • Periodic fever syndromes
  • Malaria
  • Typhoid fever
  • Rocky Mountain spotted fever
  • Ascariasis
  • Tularemia
  • Brucellosis
  • Psittacosis
  • Q fever
  • Pheochromocytoma
  • Hyperthyroidism
  • Munchausen syndrome
  • Dengue fever
完整详情

撰稿人

作者

William F. Wright, DO, MPH

Assistant Professor

Division of Infectious Diseases, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

利益声明

WFW declares that he has no competing interests. WFW is an author of references cited in this topic.

Paul G. Auwaerter​,, MD

Professor

Division of Infectious Diseases, Department of Medicine

The Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases

Johns Hopkins University School of Medicine

Baltimore

MD

利益声明

PGA declares that he has no competing interests. PGA is an author of references cited in this topic.

鸣谢

Dr William F. Wright and Dr Paul G. Auwaerter would like to gratefully acknowledge Dr Roth and Dr Basello, previous contributors to this topic.

同行评议者

Kevin P. High, MD, MS, MACP, FIDSA

Professor of Medicine

Wake Forest University School of Medicine

Vice Chief Academic Officer, aLHS, Advocate Health

Winston-Salem

NC

利益声明

KPH declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

参考文献

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

关键文献

Haidar G, Singh N. Fever of unknown origin. N Engl J Med. 2022 Feb 3;386(5):463-77. 摘要

Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med. 2015 Oct;128(10):1138.e1-1138.e15.全文  摘要

Wright WF, Auwaerter PG. Fever and fever of unknown origin: review, recent advances, and lingering dogma. Open Forum Infect Dis. 2020 May;7(5):ofaa132.全文  摘要

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

内容使用需遵循免责声明