Última revisão: 26 Mar 2025
Última atualização: 18 Sep 2024
Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- upper and lower respiratory tract involvement
- renal involvement
- constitutional features
Detalhes completos
Outros fatores diagnósticos
- ocular manifestations
- cutaneous manifestations
- musculoskeletal manifestations
- neurologic manifestations
- signs or symptoms of thromboembolism
- gastrointestinal involvement
- cardiac involvement
- breast mass
- lower genitourinary tract involvement
- endocrine involvement
- isolated mass lesions/focal granuloma
Detalhes completos
Fatores de risco
- genetic predisposition
- infection
- environmental exposures
- white ethnicity
Detalhes completos
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- urinalysis and microscopy
- CT chest
- antineutrophil cytoplasmic antibody (ANCA)
- CBC and differential
- serum creatinine
- C-reactive protein
- erythrocyte sedimentation rate (ESR)
- liver function tests
- serum calcium
Detalhes completos
Investigações a serem consideradas
- tissue biopsy
- pulmonary function testing
- bronchoscopy
- electromyography/nerve conduction studies
- upper airway endoscopy
- CT sinuses
Detalhes completos
Algoritmo de tratamento
AGUDA
severe (life/organ-threatening) disease: remission induction
nonsevere (non-life/organ-threatening) disease: remission induction
CONTÍNUA
remission successfully induced
relapse following successful remission
Colaboradores
Autores
Eamonn Molloy, MD, MS, FRCPI
Consultant Rheumatologist
Department of Rheumatology
St Vincent's University Hospital
Dublin
Ireland
Declarações
EM declares that he has been a speaker for, and participated in advisory board for Abbvie, Janssen, Gilead, Novartis. He has received sponsorship to attend conferences from Abbvie, Janssen and UCB, and received research funding from Abbvie.
Revisores
Curry L. Koening, MD, MS
Assistant Professor of Medicine
Rheumatology Division
University of Utah School of Medicine
Salt Lake City
UT
Declarações
CLK declares that he has no competing interests.
Jaap M. van Laar, MD, PhD
Professor of Clinical Rheumatology
Musculoskeletal Research Group
Institute of Cellular Medicine
Newcastle University
The Medical School
Newcastle upon Tyne
UK
Declarações
JMVL declares that he has no competing interests.
Diagnósticos diferenciais
- Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome)
- Microscopic polyangiitis (MPA)
- Classic polyarteritis nodosa (cPAN)
Mais Diagnósticos diferenciaisGuidelines
- KDIGO 2024 clinical practice guideline for the management of antineutrophil cytoplasmic antibody (ANCA) associated vasculitis
- Guideline for vaccinations in patients with rheumatic and musculoskeletal disease
Mais GuidelinesLog in or subscribe to access all of BMJ Best Practice
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