Summary
Definition
History and exam
Key diagnostic factors
- upper and lower respiratory tract involvement
- renal involvement
- constitutional features
Other diagnostic factors
- ocular manifestations
- cutaneous manifestations
- musculoskeletal manifestations
- neurological manifestations
- signs or symptoms of thromboembolism
- white ethnicity
- gastrointestinal involvement
- cardiac involvement
- breast mass
- lower GU tract involvement
- endocrine involvement
- isolated mass lesions/focal granuloma
Diagnostic investigations
1st investigations to order
- urinalysis and microscopy
- CT chest
- anti-neutrophil cytoplasmic antibody (ANCA)
- FBC and differential
- serum creatinine
- erythrocyte sedimentation rate (ESR)
Investigations to consider
- tissue biopsy
- pulmonary function testing
- bronchoscopy
- electromyography/nerve conduction studies
- upper airway endoscopy
- CT sinuses
Treatment algorithm
Contributors
Authors VIEW ALL
Consultant Rheumatologist
Department of Rheumatology
St Vincent's University Hospital
Dublin
Ireland
Disclosures
EM declares that he has participated in local advisory boards for Pfizer, Roche, BMS, MSD, and Novartis. He has received conference travel/accommodation expenses from Pfizer, Roche, Abbvie, and MSD. The organisation he works for has an unrestricted educational grant from Roche to support regional educational meetings.
Peer reviewers VIEW ALL
Assistant Professor of Medicine
Rheumatology Division
University of Utah School of Medicine
Salt Lake City
UT
Disclosures
CLK declares that he has no competing interests.
Professor of Clinical Rheumatology
Musculoskeletal Research Group
Institute of Cellular Medicine
Newcastle University
The Medical School
Newcastle upon Tyne
UK
Disclosures
JMVL declares that he has no competing interests.
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