Resumo
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- splenomegaly
- shortness of breath
- left upper quadrant discomfort or fullness
- epistaxis
- arthralgia
- sternal tenderness
Другие диагностические факторы
- weight loss
- excessive sweating
- fever
- pallor
- bruising
- retinal hemorrhages
Факторы риска
- age 65 to 74 years
- ionizing radiation exposure
- male sex
Диагностические исследования
Исследования, которые показаны в первую очередь
- CBC
- complete metabolic profile
- peripheral blood smear
- bone marrow aspirate and biopsy for cytogenetic analysis
- quantitative reverse transcription PCR (qRT-PCR) including breakpoint analysis
- fluorescence in situ hybridization (FISH)
Исследования, проведение которых нужно рассмотреть
- mutational analysis
Алгоритм лечения
chronic phase
accelerated phase
Составители
Авторы
Michael J. Mauro, MD
Leader, Myeloproliferative Neoplasms Program, Leukemia Service
Attending Physician and Member
Memorial Sloan Kettering Cancer Center
Professor, Weill Cornell Medicine
New York
NY
Раскрытие информации
MJM has received institutional research support for clinical trials from Novartis, Bristol Myers Squibb, Takeda, and Sun Pharma/Sparc, and honoraria for consulting/advisory boards from Novartis, Bristol Myers Squibb, Takeda, and Pfizer.
Выражение благодарностей
Dr Michael Mauro would like to gratefully acknowledge Dr Tim Somervaille, Dr Han Myint, and Dr Robert Chen, the previous contributors to this topic.
Раскрытие информации
TS has received travel support and speaker expenses from Novartis, and has served as a consultant to Novartis for development of drugs for indications other than CML. HM sits on the advisory board of Novartis and Bristol Myers Squibb, and also does speaking engagements on their behalf. RC declares that he has no competing interests.
Рецензенты
Rebecca Connor, MD
Chief Fellow
Section of Hematology and Oncology
Department of Internal Medicine
Wake Forest University Baptist Medical Center
Winston-Salem
NC
Раскрытие информации
RC declares that she has no competing interests.
Richard E. Clark, MA, MD, FRCP, FRCPath
Professor of Haematology
Royal Liverpool University Hospital
Liverpool
UK
Раскрытие информации
None disclosed.
Список литературы
Основные статьи
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: chronic myeloid leukemia [internet publication].Полный текст
Hochhaus A, Baccarani M, Silver RT, et al. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. Leukemia. 2020 Apr;34(4):966-84.Полный текст Аннотация
Hochhaus A, Saussele S, Rosti G, et al. Chronic myeloid leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017 Jul 1;28(Suppl 4):iv41-51.Полный текст Аннотация
Smith G, Apperley J, Milojkovic D, et al. A British Society for Haematology guideline on the diagnosis and management of chronic myeloid leukaemia. Br J Haematol. 2020 Oct;191(2):171-93.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Leukemoid reaction
- Benign neutrophilic leukocytosis
- Atypical CML
Больше ОтличияРекомендации
- NCCN clinical practice guidelines in oncology: chronic myeloid leukemia
- NCCN clinical practice guidelines in oncology: hematopoietic cell transplantation (HCT)
Больше РекомендацииКалькуляторы
EUTOS long-term survival (ELTS) score
Sokal score for chronic myeloid leukemia
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