小结
定义
病史和体格检查
诊断性检查
治疗流程
撰稿人
作者
Jacqueline C. Barrientos, MD, MS
Associate Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research & Treatment Program
Northwell Health Cancer Institute
Lake Success, NY
利益声明
JCB has been a consultant for Beigene, Abbvie, and AstraZeneca; received honoraria from Janssen; and received research funding from Oncternal, VelosBio, and Pharmacyclics.
Joanna M. Rhodes, MD, MSCE
Assistant Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research and Treatment Program
Northwell Health Cancer Institute
Lake Success, NY
利益声明
JMR has received consulting fees from AbbVie, ADC Therapeutics, AstraZeneca, BeOne, BMS, Epizyme, Genentech, GenMab, Janssen, Johnson & Johnson, MorphoSys, Pharmacyclics, Seagen, TG Therapeutics, Verastem, Pfizer, and Incyte. JMR’s institution has received research support from AbbVie, Acerta, ADC Therapeutics, AstraZeneca, Acrotech, BeOne, Janssen, Johnson & Johnson, Loxo Oncology, Oncternal Therapeutics, Pharmacyclics, VelosBio, and Merck.
鸣谢
Dr Jacqueline C. Barrientos and Dr Joanna M. Rhodes would like to gratefully acknowledge Dr Vidhya Murthy, Dr Shankaranarayana Paneesha, and Dr Robert Chen, previous contributors to this topic.
利益声明
VM has received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014. SP has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda. RC declares that he has no competing interests.
同行评议者
Alessandra Ferrajoli, MD
Associate Medical Director, Professor
Department of Leukemia Center
The University of Texas MD Anderson Cancer Center
Houston, TX
利益声明
AF declares that she has no competing interests.
Farrukh Awan, MD
Professor of Medicine
Department of Internal Medicine
UT Southwestern Medical Center
Dallas, TX
利益声明
FA declares that he has no competing interests.
Paolo F. Caimi, MD
Associate Professor
Department of Medicine
Case Western Reserve University
Case Comprehensive Cancer Center
Cleveland, OH
利益声明
PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.
Daniel Catovsky, MD, FRCP, FRCPath, DSc, FMedSc
Consultant Haemato-oncologist
Section of Haemato-Oncology
The Institute of Cancer Research
Sutton
UK
利益声明
Unfortunately, we have since been made aware that DC is deceased
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018 Jun 21;131(25):2745-60.全文 摘要
Walewska R, Parry-Jones N, Eyre TA, et al. Guideline for the treatment of chronic lymphocytic leukaemia. Br J Haematol. 2022 Jun;197(5):544-57.全文 摘要
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: chronic lymphocytic leukemia/small lymphocytic lymphoma [internet publication].全文
Eichhorst B, Robak T, Montserrat E, et al; ESMO Guidelines Committee. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Jan;32(1):23-33.全文 摘要
Hallek M, Al-Sawaf O. Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures. Am J Hematol. 2021 Dec 1;96(12):1679-705.全文 摘要
参考文献
A full list of sources referenced in this topic is available here.
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