Chronic lymphocytic leukemia
Summary
Definition
History and exam
Diagnostic tests
Tests to consider
- serum beta-2 microglobulin
- fluorescent in situ hybridization (FISH)
- molecular genetic tests
- direct antiglobulin test (DAT)
- serum quantitative immunoglobulin
- lymph node biopsy
- bone marrow aspirate and trephine biopsy
- CT scan/fluorodeoxyglucose (FDG)-PET/CT
Treatment algorithm
Contributors
Authors
Jacqueline C. Barrientos, MD, MS
Associate Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research & Treatment Program
Northwell Health Cancer Institute
Lake Success
NY
გაფრთხილება:
JCB has been a consultant for Beigene, Abbvie, and AstraZeneca; received honoraria from Janssen; and received research funding from Oncternal, VelosBio, and Pharmacyclics.
Joanna M. Rhodes, MD, MSCE
Assistant Professor
Department of Medicine
Zucker School of Medicine at Hofstra/Northwell
CLL Research and Treatment Program
Northwell Health Cancer Institute
Lake Success
NY
გაფრთხილება:
JMR has received fees for consulting for Abbvie, Genentech, Pharmacyclics, Beigene, AstraZeneca, Morphosys, Epizyme, ADC Therapeutic, TG Therapeutics, Versatem, SeaGen, and Jannsen. JMR’s institution has received research support from Oncternal Pharmaceutics, Pharmacyclics, Acerta, Loxo Oncology, Velosbios, Abbvie, and AstraZeneca.
მადლიერება
Dr Jacqueline C. Barrientos and Dr Joanna M. Rhodes would like to gratefully acknowledge Dr Vidhya Murthy, Dr Shankaranarayana Paneesha, and Dr Robert Chen, previous contributors to this topic.
გაფრთხილება:
VM has received a consultancy fee from Janssen, and a grant from Takeda for the ASH Annual Meeting 2014. SP has received consultancy and speaker fees from Janssen, Gilead, AbbVie, Bristol-Myers Squibb, and Takeda. RC declares that he has no competing interests.
რეცენზენტები
Alessandra Ferrajoli, MD
Associate Medical Director, Professor
Department of Leukemia Center
The University of Texas MD Anderson Cancer Center
Houston
TX
გაფრთხილება:
AF declares that she has no competing interests.
Farrukh Awan, MD
Professor of Medicine
Department of Internal Medicine
UT Southwestern Medical Center
Dallas
TX
გაფრთხილება:
FA declares that he has no competing interests.
Paolo F. Caimi, MD
Associate Professor
Department of Medicine
Case Western Reserve University
Case Comprehensive Cancer Center
Cleveland
OH
გაფრთხილება:
PFC has received honoraria from Celgene for participation in a speaker bureau, and from Kite Pharma for participation in an advisory board.
Daniel Catovsky, MD, FRCP, FRCPath, DSc, FMedSc
Consultant Haemato-oncologist
Section of Haemato-Oncology
The Institute of Cancer Research
Sutton
UK
გაფრთხილება:
Unfortunately, we have since been made aware that DC is deceased
რეცენზენტების განცხადებები
BMJ Best Practice-ის თემების განახლება სხვადასხვა პერიოდულობით ხდება მტკიცებულებებისა და რეკომენდაციების განვითარების შესაბამისად. ქვემოთ ჩამოთვლილმა რეცენზენტებმა თემის არსებობის მანძილზე კონტენტს ერთხელ მაინც გადახედეს.
გაფრთხილება
რეცენზენტების აფილიაციები და გაფრთხილებები მოცემულია გადახედვის მომენტისთვის.
References
Key articles
Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018 Jun 21;131(25):2745-60.Full text Abstract
Walewska R, Parry-Jones N, Eyre TA, et al. Guideline for the treatment of chronic lymphocytic leukaemia. Br J Haematol. 2022 Jun;197(5):544-57.Full text Abstract
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: chronic lymphocytic leukemia/small lymphocytic lymphoma [internet publication].Full text
Eichhorst B, Robak T, Montserrat E, et al; ESMO Guidelines Committee. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Jan;32(1):23-33.Full text Abstract
Hallek M, Al-Sawaf O. Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures. Am J Hematol. 2021 Dec 1;96(12):1679-705.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available here.
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