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Renal cell carcinoma

Última revisão: 13 Feb 2025
Última atualização: 12 Dec 2024

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • asymptomatic (incidental finding)
  • hematuria
  • flank pain
  • palpable abdominal mass
Detalhes completos

Outros fatores diagnósticos

  • nonspecific systemic symptoms
  • signs of hepatic dysfunction
  • myoneuropathy
  • lower limb edema
  • scrotal varicocele
  • dermatologic manifestation (hereditary syndromes)
  • vision loss (von Hippel-Lindau)
Detalhes completos

Fatores de risco

  • smoking
  • male sex
  • age over 55 years
  • residence in developed countries
  • non-Hispanic American Indian/Alaska Native ethnicity
  • obesity
  • hypertension
  • positive family history of RCC
  • history of hereditary syndromes
  • history of acquired renal cystic disease
  • asbestos/cadmium exposure
  • obstetric history/estrogen exposure
  • pelvic radiation
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • CT abdomen/pelvis
  • CT chest
  • MRI abdomen/pelvis
  • abdominal/pelvic ultrasound
  • CBC
  • LDH
  • corrected calcium
  • liver function tests
  • coagulation profile
  • creatinine
  • estimated GFR
  • urinalysis
Detalhes completos

Investigações a serem consideradas

  • MRI brain/spine
  • bone scan
  • biopsy
  • surgical pathology
  • genetic evaluation
Detalhes completos

Novos exames

  • PET scan

Algoritmo de tratamento

CONTÍNUA

small renal mass or RCC stage 1 or 2

RCC stage 3

RCC stage 4 (metastatic disease)

Colaboradores

Autores

Rodrigo R. Pessoa, MD, PhD

Urology Fellow

Department of Urology

Mayo Clinic

Rochester

MN

Declarações

RRP declares that he has no competing interests.

Simon Kim, MD, MPH

Associate Professor of Surgery

Associate Program Director

Anschutz Medical Campus

University of Colorado

UCSOM Division of Urology 

Denver

CO

Declarações

SK declares that he has no competing interests.

Agradecimentos

Dr Rodrigo R. Pessoa and Dr Simon Kim would like to gratefully acknowledge Dr Amishi Y. Shah, Dr Sonal Gandhi, and Jennifer J. Knox, previous contributors to this topic.

Declarações

AYS has an unpaid advisory role for Merck pharmaceuticals. SG and JJK declare that they have no competing interests.

Revisores

Stephen A. Boorjian, MD

Assistant Professor

Fox Chase Cancer Center

Philadelphia

PA

Declarações

SAB has been reimbursed by Pfizer for serving on its speakers bureau. SAB is co-author of a reference cited in this topic.

Thomas J. Guzzo, MD, MPH

Assistant Professor of Urology and Surgery

The Hospital of the University of Pennsylvania

Philadelphia

PA

Declarações

TJG declares that he has no competing interests.

Jonathan Waxman, BSc, MBBS, MD, FRCP

Professor of Oncology

Imperial College

London

UK

Declarações

JW declares that he has no competing interests.

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