Evaluation of delirium

Overview 
Theory 
Emergencies 
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Last reviewed: 24 Sep 2025

Last updated: 02 Oct 2025

Introduction

Delirium is an acute, fluctuating change in mental status, with inattention, disorganized thinking, and altered levels of consciousness.[1] It is a potentially life-threatening disorder characterized by high morbidity and mortality. Guidelines address recognition, risk factors, and treatment for delirium.[2][3][4]

Adverse sequelae

Mortality for those diagnosed with delirium in the hospital is twice that of patients with similar medical conditions without delirium, and may be as high as 14% within 1 month of diagnosis.[5]

Delirium is common in the intensive care unit, especially among mechanically ventilated patients. In critically ill patients, it is associated with an increased length of stay and increased mortality.[6][7]

Delirium is associated with elevated risks for functional and cognitive decline, poor rehabilitation potential, institutionalization, and rehospitalization.[1][7][8][9][10][11] While delirium has been considered to be a reversible condition, studies suggest that delirium symptoms can last for weeks to months following onset.[12] Persistent delirium has been found to be frequent in older hospitalized patients, and associated with adverse outcomes.[13] There is growing evidence that delirium may be an independent risk factor for longer term cognitive decline.[14]

Classification

The Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) notes that in order to be diagnosed with delirium, a patient must show all 4 of the following features.[15]

A disturbance in attention (i.e., reduced clarity of awareness of the environment) is evident, with reduced ability to focus, sustain, or shift attention. This disturbance in consciousness might be subtle, initially presenting solely as lethargy or distractibility, and might be frequently dismissed by clinicians and/or family members as being related to the primary illness.
A change in cognition (such as memory deficit, disorientation, language disturbance) or the development of a perceptual disturbance not better accounted for by a pre-existing or evolving dementia.
The disturbance develops over a short period of time (usually hours to days), represents an acute change from baseline, and tends to fluctuate during the course of the day.
There is evidence from the history, physical exam, or laboratory findings that the disturbance is caused by the direct physiologic consequences of a general medical condition, substance intoxication, or substance withdrawal. The changes in attention and cognition must not occur in the context of a severely reduced level of arousal, such as coma.

Three clinical subtypes of delirium have been identified.[16][17][18] These include:

Hyperactive delirium - a condition where a patient might have heightened arousal, with restlessness, agitation, hallucinations, and inappropriate behavior
Hypoactive delirium - a condition where a patient might display lethargy, reduced motor activity, incoherent speech, and lack of interest
Mixed delirium - a combination of hyperactive and hypoactive signs and symptoms.

The term subsyndromal delirium has also been used to define partially resolved or incomplete forms of delirium.

Epidemiology

Delirium occurs in ≥20% of hospitalizations annually, and is the most common hospital-related complication in the US.[19][20][21] Prevalence of delirium ranges from 10% to 40% in older hospitalized patients.[19]

Delirium affects up to 35% of people on medical floors.[3][14] Prevalence ranges from: 8% to 18% in the emergency department; 15% to 53% for postoperative patients; and 7% to 50% for intensive care patients.[22][23][24][25] The incidence and prevalence of delirium in medical inpatients appears to have remained broadly stable over the past four decades.[26]

The prevalence of delirium in the community is believed to be 1% to 2%, a figure that increases to 10% for patients ages >85 years.[27]

Delirium is frequently under-recognized. This may be indicative of the fluctuating nature of delirium symptoms, and an overall underappreciation of its clinical significance.

Pathophysiology

The pathophysiology of delirium remains relatively unclear. In general, neuroimaging studies reveal disruptions in higher cortical functioning in multiple disparate areas of the brain, including the prefrontal cortex, subcortical structures, thalamus, basal ganglia, lingual gyri, and frontal, fusiform and temporoparietal cortex.[28][29] Electroencephalographic (EEG) studies show diffuse slowing of cortical activity.

Theories on the pathogenesis of delirium point to the role of neurotransmitters, inflammation, and chronic stress on the brain. For example, the role of cholinergic deficiency in inducing delirium is strengthened by the clear association of anticholinergic drug use with increased incidence.[30] Studies in surgical patients have demonstrated a dysfunctional interaction between the cholinergic and immune systems in patients who developed postoperative delirium.[31]

Dopaminergic excess is also believed to contribute. Evidence does not appear to support the use of antipsychotic drugs (dopamine antagonists) for the prevention or treatment of delirium, but is not entirely consistent.[32][33][34][35][36][37][38][39] Other neurotransmitters implicated in the pathophysiology of delirium include norepinephrine, serotonin, gamma-aminobutyric acid, glutamate, and melatonin.

Cytokines, including interleukins 1 and 2, TNF-alpha, and interferon, may contribute to delirium onset.[40] Chronic hypercortisolism, as induced by chronic stress secondary to illness or trauma, may contribute to delirium initiation.[41][42]

Diagnósticos diferenciais

comuns

Dementia
Pain
Stroke and transient ischemic attack
Myocardial infarction
Acute systemic infection
Hypoglycemia
Hyperglycemia
Hypoxia
Hypercapnia
Acute urinary obstruction
Drug- or illicit drug-related
Alcoholic ketoacidosis
Hepatic encephalopathy
Renal failure
Hypernatremia
Hyponatremia
Hypercalcemia
Meningitis/encephalitis
Brain tumor
Postictal state
Dehydration (volume depletion)
Constipation

Detalhes completos

Incomuns

Traumatic head injury
Adrenal crisis
Thyrotoxicosis
Myxedema coma
Brain abscess
Neurosyphilis
Wernicke encephalopathy

Detalhes completos

Colaboradores

Autores

Natalia Jaworska, MD, MSc, FRCPC

Intensivist and Clinical Assistant Professor

Department of Critical Care Medicine

University of Calgary

Calgary

Canada

Declarações

NJ has held and holds several grants from the University of Calgary and Alberta Health Services related to the topic of sedation and delirium prevention in critically ill adult patients. The University of Calgary and Alberta Health Services did not play any role in the development or administration of the research projects.

Agradecimentos

Dr Natalia Jaworska would like to gratefully acknowledge Dr Margret Pisani and David M. Dosa, previous contributors to this topic.

Declarações

MP and DMD declare that they have no competing interests.

Revisores

Marquis Foreman, PhD, RN, FAAN

Professor and Associate Dean for Nursing Science Studies

College of Nursing

University of Illinois at Chicago

Declarações

MF declares that he has no competing interests.

Andrew Parfitt, MBBS, FFAEM

Clinical Director

Acute Medicine

Associate Medical Director

Consultant Emergency Medicine

Guy's and St Thomas' NHS Foundation Trust

Clinical Lead and Consultant

Accident Emergency Medicine

St Thomas' Hospital

London

Declarações

AP declares that he has no competing interests.

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Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Devlin JW, Skrobik Y, Gélinas C, et al; American College of Critical Care Medicine. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-e73.Texto completo Resumo

National Institute for Health and Care Excellence. Delirium: prevention, diagnosis and management in hospital and long-term care. Jan 2023 [internet publication].Texto completo

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022

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Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.

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Evaluation of delirium

Summary

Introduction

Adverse sequelae

Classification

Epidemiology

Pathophysiology

Diagnósticos diferenciais

comuns

Incomuns

Colaboradores

Autores

Natalia Jaworska, MD, MSc, FRCPC

Declarações

Agradecimentos

Declarações

Revisores

Marquis Foreman, PhD, RN, FAAN

Declarações

Andrew Parfitt, MBBS, FFAEM

Declarações

Créditos aos pareceristas

Declarações

Referências

Principais artigos

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.

Videos

Conectar-se ou assinar para acessar todo o BMJ Best Practice

Conectar-se ou assinar para acessar todo o BMJ Best Practice

Conectar-se para acessar todo o BMJ Best Practice