小结
定义
病史和体格检查
关键诊断因素
- fatigue
- dry eyes
- dry mouth
其他诊断因素
- vasculitis
- dental caries
- increased oral fungal and bacterial infections
- musculoskeletal pain
- thyroid disease
- urogenital disease
- pulmonary disease
- gastrointestinal disease
- peripheral neuropathy
- corneal ulceration
- no saliva pool
- enlarged salivary glands
- facial pain
- burning mouth syndrome
危险因素
- female
- systemic lupus erythematosus (SLE)
- rheumatoid arthritis
- systemic sclerosis (scleroderma)
- HLA class II markers
- age 40 to 70
- genetic inheritance
诊断性检查
首要检查
- Schirmer test
- anti-60 kD (SS-A) Ro and anti-La (SS-B)
需考虑的检查
- sialometry
- minor salivary gland biopsy
- lissamine green test
- fluorescein corneal staining test
- parotid sialography
- salivary gland technetium-99m pertechnetate scintigraphy
- skin biopsy
- angiography
- urinalysis
- serum electrolytes
新兴检查
- MRI salivary glands
- ultrasound salivary glands
治疗流程
dry eyes
dry mouth
with fatigue
with musculoskeletal manifestations
with vasculitis
with renal tubular acidosis
with neuropathy
撰稿人
作者
Biji T. Kurien, PhD
Staff Scientist
Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Research Associate
Department of Veterans Affairs
Oklahoma City
OK
利益声明
BTK is an author of several articles cited in this topic.
R. Hal Scofield, MD
Professor
Section of Endocrinology and Diabetes
Department of Medicine
University of Oklahoma Health Sciences Center
Member
Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Associate Chief of Staff for Research and Staff Physician
Department of Veterans Affairs Medical Center
Oklahoma City
OK
利益声明
RHS has received compensation from Jessen Pharmaceuticals as a member of a clinical trial advisory board, and honorarium from Merck and Company for consultation on an investigational agent for Sjogren’s syndrome. RHS is the principal investigator for grants from the US National Institute of Health and the US Department of Veteran Affairs for institutions studying Sjorgren’s syndrome. RHS is an author of several articles cited in this topic.
同行评议者
Nora Sandorfi, MD
Associate Professor of Medicine
University of Pennsylvania
Philadelphia
PA
利益声明
NS declares she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Foulks GN, Forstot SL, Donshik PC, et al. The Sjogren's Syndrome Foundation clinical practice guidelines. Ocular management in Sjogren's patients. 2015 [internet publication].全文
Vivino FB, Zero D, Brennan M, et al. Sjogren's Syndrome Foundation's clinical practice guidelines. Oral management: caries prevention in Sjogren's patients. 2015 [internet publication].全文
Carsons SE, Vivino FB, Parke A, et al. Treatment guidelines for rheumatologic manifestations of Sjögren's syndrome: use of biologic agents, management of fatigue, and inflammatory musculoskeletal pain. Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-27.全文 摘要
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
鉴别诊断
- Systemic lupus erythematosus (SLE)
- Rheumatoid arthritis
- Hepatitis C
更多 鉴别诊断指南
- 2023 American College of Rheumatology (ACR) guideline for the treatment of interstitial lung disease in people with systemic autoimmune rheumatic disease
- 2022 American College of Rheumatology guideline for vaccinations in patients with rheumatic and musculoskeletal disease
更多 指南
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